Endovascular intervention is a game-changer in the history of modern medicine. It provides an alternative modality to open surgery and medication for treating vascular diseases. This type of minimally invasive procedure originates from innovative medical devices and biomaterials and allows for a small incision, low risk, and short hospitalization.

The primary endovascular interventional devices include introducer sheaths, guidewires, catheters, angioplasty balloons, and implants for stenting and embolization. Each device encompasses a wide spectrum of biomaterials to meet various clinical scenarios. Using stents as an example, 316L stainless steel is the most common material but with a high rate of restenosis; recently cobalt chromium is taking the place as a balloon-expandable stent material, and nitinol as a shape-memory alloy is particularly suited for a self-expanding stent. Successful embolization at different lesions also relies on a variety of embolic candidates, including metal coils, polymer particulates, and liquid/glue. Additionally, surface drug and polymer coatings play an integral part to facilitate the procedure. A high-density biomaterial with radiopacity is necessary for visualization under fluoroscopy. Therefore, understanding and selection of the right biomaterials is essential for procedural success and clinical outcome of the interventional operation. A collection of studies highlighting biomaterials in endovascular intervention will certainly attract attention from engineers, scientists, and clinicians in many disciplines.

The goal of this Special Issue is to solicit both research articles and review articles in endovascular intervention with respect to biomaterials. Researchers are encouraged to submit original and interdisciplinary work related to biomaterials analysis, manufacturing, testing, and clinical applications. Basic, translational, and clinical research is welcome.

Potential topics include but are not limited to the following:

• New biomaterials for endovascular intervention
• Embolic materials and clinical applications
• Clinical studies of on-label/off-label embolization materials
• Stent materials and clinical applications
• Clinical studies of on-label/off-label stent materials
• Micro/nanomaterials for interventional operations
• 3D printed medical devices
• Biodegradable materials for implantable devices