BioMed Research International

Pharmacological Application of Antiradical Compound Properties


Publishing date
25 Oct 2013
Status
Published
Submission deadline
07 Jun 2013

1Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite 245, 90050-170 Porto Alegre, RS, Brazil

2Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, RS, Brazil

3Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK

4Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Pelotas, RS, Brazil


Pharmacological Application of Antiradical Compound Properties

Description

The production of reactive oxygen species (ROS) is part of human metabolism and participates in various physiological mechanisms, such as cytochrome P450-mediated oxidations, regulation of smooth muscle tone, and killing microorganisms. However, when the rate of ROS production exceeds the rate of removal by cellular defenses, oxidative stress occurs, which can activate a variety of transcription factors and thus lead to the expression of a wide variety of genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules, and anti-inflammatory molecules.

In recent years, increasing evidence implicates ROS in a variety of diseases and pathophysiological events including inflammation, cancer, cardiovascular disease, Alzheimer's disease, Parkinson's disease, and acute respiratory distress syndrome. This involvement suggests that antioxidant molecules can be useful to treat different diseases. Biological research on antioxidants and free radicals has produced promising results regarding new therapeutic approaches.

Natural and synthetic antioxidants can exert their effect in different ways. Antioxidant action can be attributed to direct scavenging capacity, stimulating endogenous antioxidant and/or activating physiological response.

Antioxidant therapies have emerged as an alternative for treating and/or preventing chronic degenerative diseases including cancer, cardiovascular diseases, inflammation, and neurodegenerative diseases. Potential topics include, but are not limited to:

  • Free-radical scavenging properties of natural compounds
  • Antiradical properties of synthetic molecules
  • Design of metal chelating agents
  • Biotechnology in antiradical systems
  • Antioxidants as a new therapeutic approach
  • Antioxidants and their benefits to health
  • Endogenous antioxidants
  • Antioxidants, longevity, and aging

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/pharmacology/acp/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 989604
  • - Editorial

Pharmacological Application of Antiradical Compound Properties

Alethéa Gatto Barschak | Francieli Moro Stefanello | ... | Wilson João Cunico Filho
  • Special Issue
  • - Volume 2013
  • - Article ID 147307
  • - Research Article

Phytic Acid Inhibits Lipid Peroxidation In Vitro

Alicja Zajdel | Adam Wilczok | ... | Zofia Dzierżewicz
  • Special Issue
  • - Volume 2013
  • - Article ID 821498
  • - Research Article

Possible Mechanisms of Fullerene C60 Antioxidant Action

V. A. Chistyakov | Yu. O. Smirnova | ... | A. V. Soldatov
  • Special Issue
  • - Volume 2013
  • - Article ID 918039
  • - Review Article

Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues

Yong Son | Ju Hwan Lee | ... | Hyun-Ock Pae
  • Special Issue
  • - Volume 2013
  • - Article ID 924870
  • - Research Article

Protective Effect of Spin-Labeled 1-Ethyl-1-nitrosourea against Oxidative Stress in Liver Induced by Antitumor Drugs and Radiation

V. Gadjeva | B. Grigorov | ... | M. Vasileva
  • Special Issue
  • - Volume 2013
  • - Article ID 132759
  • - Research Article

Antioxidant Properties of Brazilian Tropical Fruits by Correlation between Different Assays

Elena Gregoris | Giuseppina Pace Pereira Lima | ... | Roberto Stevanato
  • Special Issue
  • - Volume 2013
  • - Article ID 972028
  • - Research Article

Evaluation of In Vivo Wound Healing Activity of Bacopa monniera on Different Wound Model in Rats

S. Murthy | M. K. Gautam | ... | R. K. Goel
  • Special Issue
  • - Volume 2013
  • - Article ID 469180
  • - Research Article

Effects of an Agaricus blazei Aqueous Extract Pretreatment on Paracetamol-Induced Brain and Liver Injury in Rats

Andréia A. Soares | Andrea L. de Oliveira | ... | Rosane M. Peralta
  • Special Issue
  • - Volume 2013
  • - Article ID 343914
  • - Review Article

Fructation In Vivo: Detrimental and Protective Effects of Fructose

H. M. Semchyshyn
  • Special Issue
  • - Volume 2013
  • - Article ID 437613
  • - Review Article

Molecular Basis of Cardioprotective Effect of Antioxidant Vitamins in Myocardial Infarction

Ramón Rodrigo | Matías Libuy | ... | Daniel Hasson
BioMed Research International
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Acceptance rate31%
Submission to final decision81 days
Acceptance to publication54 days
CiteScore2.410
Impact Factor2.197
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