BioMed Research International

Understanding the Molecular Mechanism and Structure-Function Relationship of the Toxicity of PLA2 and K49 Homologs in Snake Venom


Publishing date
15 Feb 2013
Status
Published
Submission deadline
26 Oct 2012

1Department of Biochemistry, Institute of Biology, State University of Campinas (UNICAMP), CP 6109, 13083-970 Campinas, SP, Brazil

2Facultad de Ciencias Exactas y Naturales y Agrimensura, Universidad Nacional del Nordeste, Corrientes, Argentina

3Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil


Understanding the Molecular Mechanism and Structure-Function Relationship of the Toxicity of PLA2 and K49 Homologs in Snake Venom

Description

Animal venoms are a rich and complex mixture of toxic and pharmacologically active proteins and peptides. Due to this broad range of biological functions, these biomolecules have been the subject of hundreds of scientific articles in different research fields, including biochemistry, biophysics, pharmacology, toxicology, and medicine.

Venoms from snakes of the family Viperidae contain class II PLA2s, which share structural features with secretory PLA2s of the class II-A present in inflammatory exudates in mammals. A number of venom PLA2s have been shown to induce a variety of pharmacological effects although comprehensive studies of the actions of venom PLA2s on the various events of toxicity are scarce. A particularly interesting subgroup of venom PLA2s includes homologs having a number of amino acid substitutions at the calcium-binding loop, especially lysine substituting aspartate at position 49, resulting in the inability of these enzymes to bind calcium and, consequently, in the abrogation of their catalytic activity. Thus, these PLA2s homologs exert their activities independently of enzymatic phospholipids degradation; the ability to induce pharmacological effects with higher potencies underscores the importance of PLA2 enzymes in snake venom toxicity.

Today, despite a series of investigations in different areas, the mechanisms of action for both variants (D49 and K49 PLA2 homologs) are not fully elucidated. We invite researchers to contribute original research articles and review articles and to encourage continued efforts to better understand the role of the catalytic activity and its absence in the homolog K49, in triggering drug events. Potential topics include, but are not limited to:

  • Phospholipases A2 and K49 homolog from snake venoms, emphasizing their biological activities in vivo and in vitro
  • Studying calcium independence of snake venom phospholipases A2 homologs (K49) pharmacologically based on the effects of synthetic peptides that identify a C-terminal region as being responsible for myotoxicity
  • Studying the snake venom phospholipases A2 as an antitumoral agent
  • Perspective of snake venom PLA2s, highlighting the variety of pharmacological activities associated with these enzymes and discussing the molecular regions involved in recognition of tissue targets
  • Reviewing the use of chemical modifications in the study of venom PLA2 and K49 homolog structure-function relationships

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jbb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 243047
  • - Editorial

Understanding the Molecular Mechanism and Structure-Function Relationship of the Toxicity of PLA2 and K49 Homologs in Snake Venom

Luis Alberto Ponce-Soto | Laura Leiva | Elen Cristina Teizem Landucci
  • Special Issue
  • - Volume 2013
  • - Article ID 391389
  • - Review Article

Antitumoral Potential of Tunisian Snake Venoms Secreted Phospholipases A2

Raoudha Zouari-Kessentini | Najet Srairi-Abid | ... | Naziha Marrakchi
  • Special Issue
  • - Volume 2013
  • - Article ID 941467
  • - Research Article

Unmasking Snake Venom of Bothrops leucurus: Purification and Pharmacological and Structural Characterization of New PL Bleu TX-III

Fábio André Marangoni | Luis Alberto Ponce-Soto | ... | Elen Cristina Teizem Landucci
  • Special Issue
  • - Volume 2013
  • - Article ID 612649
  • - Research Article

Biochemical, Pharmacological, and Structural Characterization of New Basic Bbil-TX from Bothriopsis bilineata Snake Venom

Victor Corasolla Carregari | Rafael Stuani Floriano | ... | Sergio Marangoni
  • Special Issue
  • - Volume 2013
  • - Article ID 591470
  • - Research Article

Biochemical Characterization and Pharmacological Properties of New Basic PLA2 BrTX-I Isolated from Bothrops roedingeri (Roedinger's Lancehead) Mertens, 1942, Snake Venom

Mauricio Aurelio Gomes Heleno | Paulo Aparecido Baldasso | ... | Sérgio Marangoni
  • Special Issue
  • - Volume 2013
  • - Article ID 565287
  • - Research Article

Synergistic Effects of Secretory Phospholipase A2 from the Venom of Agkistrodon piscivorus piscivorus with Cancer Chemotherapeutic Agents

Jennifer Nelson | Kristen Barlow | ... | John D. Bell
  • Special Issue
  • - Volume 2013
  • - Article ID 807982
  • - Research Article

A Lys49 Phospholipase , Isolated from Bothrops asper Snake Venom, Induces Lipid Droplet Formation in Macrophages Which Depends on Distinct Signaling Pathways and the C-Terminal Region

Karina Cristina Giannotti | Elbio Leiguez | ... | Catarina Teixeira
  • Special Issue
  • - Volume 2013
  • - Article ID 789689
  • - Research Article

Biochemical Characterization, Action on Macrophages, and Superoxide Anion Production of Four Basic Phospholipases A2 from Panamanian Bothrops asper Snake Venom

Aristides Quintero Rueda | Isela González Rodríguez | ... | Andreimar M. Soares
  • Special Issue
  • - Volume 2013
  • - Article ID 206061
  • - Research Article

Induction of Mast-Cell Accumulation by Promutoxin, an Arg-49 Phospholipase

Ji-Fu Wei | Xiao-Long Wei | ... | Shaoheng He
  • Special Issue
  • - Volume 2013
  • - Article ID 103494
  • - Research Article

Chemical Modifications of PhTX-I Myotoxin from Porthidium hyoprora Snake Venom: Effects on Structural, Enzymatic, and Pharmacological Properties

Salomón Huancahuire-Vega | Daniel H. A. Corrêa | ... | Sergio Marangoni
BioMed Research International
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