Subarachnoid hemorrhage- (SAH-) induced cerebral vasospasm is still a major cause of mortality and morbidity in patients with rupture of intracranial aneurysms. The most important and critical aspects of SAH-induced cerebral vasospasm is its failure to consistently respond to treatment. Despite the advances in pharmacological interventions, only partial success could be achieved in both experimental models and clinical trials. Although cerebral vasospasm associated with SAH has been recognized for more than half a century, the pathophysiological mechanism contributing to this form of arterial dysfunction is still illusive and more basic and clinical research is necessary to elucidate the underlying mechanisms. In addition to cerebral vasospasm, SAH-induced secondary brain injury may also contribute to a poor outcome. Accumulating data have suggested that apoptosis is a key mediator of secondary brain injury after SAH. Approximately 50% of SAH survivors remain permanently disabled because of cognitive dysfunction and do not return to their previous functions. Vasospasm alone could not explain the whole subtle changes in behavior and memory. In this aspect, apoptosis induced by global ischemia should be taken into consideration. A burgeoning number of studies have implied the impact of secondary brain injury in patients after aneurysmal SAH.

We invite investigators to contribute original research and review articles that will stimulate the continuing efforts to understand the pathophysiological mechanism of SAH-induced vasospasm and secondary brain injury, the development of strategies to treat these conditions, and the evaluation of outcomes. Potential topics include, but are not limited to:

• The mechanism of vasospasm and secondary brain injury after aneurysmal SAH
• The role of arterioles in the development of vasospasm after aneurysmal SAH
• The role of early brain injury in vasospasm and secondary brain injury after aneurysmal SAH
• Triple-H management in the treatment of vasospasm after aneurysmal SAH
• Endovascular treatment strategies for vasospasm after aneurysmal SAH
• The outcome and long-term complications after aneurysmal SAH
• Translational Medicine: Animal study to clinical application

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