BioMed Research International

PLP-Dependent Enzymes


Publishing date
27 Sep 2013
Status
Published
Submission deadline
10 May 2013

1Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, Rome, Italy

2Section of Biological Chemistry, Department of Life Sciences and Reproduction, University of Verona, Verona, Italy

3Department of Biochemistry and Molecular Biology, Faculty of Medicine, Monash University, Clayton, Australia


PLP-Dependent Enzymes

Description

Pyridoxal 5’-phosphate (PLP), the catalytically active form of vitamin B6, plays a central role in several cellular processes, acting as cofactor in more than 140 different enzyme reactions. PLP-dependent enzymes are involved in metabolism and conversion of amino acids, one-carbon units, biogenic amines, tetrapyrrolic compounds, and amino sugars. PLP-dependent enzymes play also a key role in sulfur assimilation and incorporation in cysteine, biotin, and S-adenosyl methionine. In human genome, more than fifty genes encode for the enzymes belonging to this class. The consequence of their widespread occurrence and crucial importance is that a number of PLP-dependent enzymes are current drug targets, and many others are envisaged for therapeutic intervention.

The main focus of this special issue will be on structural, functional, and biomedical studies on PLP-dependent enzymes. Papers dealing with PLP-dependent enzymes (i) that are targets of pharmacologically active compounds, (ii) whose functional deficiency or alteration causes known diseases, and (iii) whose function is unknown would be of great interest. Reviews summarizing the results of qualitative or quantitative studies and recent research on this area are particularly welcome. The special issue will become an international forum for researchers to summarize the most recent developments and ideas in the field of PLP-dependent enzymes, with a special emphasis given to applied aspects of this research area, which will allow efficient translation of proof of concepts into clinically useful agents for novel and innovative therapies. Potential topics include, but are not limited to:

  • Structure-function relationships of PLP-dependent enzymes and their complexes
  • Development and application of biophysical and biochemical methods to study the interactions between PLP-dependent enzymes and their substrates and effectors, and to investigate PLP-mediated biochemical reactions
  • Genome-scale analysis, functional genomics, and proteomics
  • Theoretical and experimental studies of metabolic pathways and networks involving PLP
  • Design and evaluation of inhibitors and drugs targeting PLP-dependent enzymes
  • Computational and theoretical studies on the evolution of this superfamily
  • Genetic engineering and biotechnology improving activity of PLP-dependent enzymes

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/biochemistry/plp/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 856076
  • - Editorial

PLP-Dependent Enzymes

Alessandro Paiardini | Roberto Contestabile | ... | Barbara Cellini
  • Special Issue
  • - Volume 2014
  • - Article ID 108516
  • - Review Article

Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?

Thales Kronenberger | Jasmin Lindner | ... | Carsten Wrenger
  • Special Issue
  • - Volume 2013
  • - Article ID 194371
  • - Research Article

The Pyridoxal 5′-Phosphate (PLP)-Dependent Enzyme Serine Palmitoyltransferase (SPT): Effects of the Small Subunits and Insights from Bacterial Mimics of Human hLCB2a HSAN1 Mutations

Ashley E. Beattie | Sita D. Gupta | ... | Dominic J. Campopiano
  • Special Issue
  • - Volume 2013
  • - Article ID 701536
  • - Research Article

Characterization of C-S Lyase from C. diphtheriae: A Possible Target for New Antimicrobial Drugs

Alessandra Astegno | Alejandro Giorgetti | ... | Paola Dominici
  • Special Issue
  • - Volume 2013
  • - Article ID 353270
  • - Research Article

Asymmetry of the Active Site Loop Conformation between Subunits of Glutamate-1-semialdehyde Aminomutase in Solution

Barbara Campanini | Stefano Bettati | ... | Roberto Contestabile
  • Special Issue
  • - Volume 2013
  • - Article ID 687658
  • - Review Article

Protein Homeostasis Defects of Alanine-Glyoxylate Aminotransferase: New Therapeutic Strategies in Primary Hyperoxaluria Type I

Angel L. Pey | Armando Albert | Eduardo Salido
  • Special Issue
  • - Volume 2013
  • - Article ID 458571
  • - Research Article

Structure-Based Mechanism for Early PLP-Mediated Steps of Rabbit Cytosolic Serine Hydroxymethyltransferase Reaction

Martino L. Di Salvo | J. Neel Scarsdale | ... | H. Tonie Wright
  • Special Issue
  • - Volume 2013
  • - Article ID 851428
  • - Review Article

Extremophilic SHMTs: From Structure to Biotechnology

Sebastiana Angelaccio
  • Special Issue
  • - Volume 2013
  • - Article ID 161456
  • - Research Article

Interaction of Human Dopa Decarboxylase with L-Dopa: Spectroscopic and Kinetic Studies as a Function of pH

Riccardo Montioli | Barbara Cellini | ... | Carla Borri Voltattorni
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