Hypertension is a public health concern worldwide because of its rising prevalence and concomitant risks of cardiovascular diseases. As the leading cause of global death, the exploding pandemic of cardiovascular disease is attributable to the clustering of risk factors that are ubiquitous but largely preventable. Multimorbidity - the presence of two or more coexisting long-term conditions - has become particularly common in hypertensive patients. Primary care, as a highly effective and efficient approach, is well-positioned to handle the emerging challenges that threaten the outcomes of health and well-being.

Although knowledge on addressing hypertension and concomitant cardiovascular disease risk has been translated into international guidelines, challenges and research gaps still exist in the understanding of the epidemiological, clinical, therapeutic, and service aspects of hypertension management in the context of population ageing and multimorbidity. As a global health research priority, coping strategies for high blood pressure and cardiovascular multimorbidity may encompass a full spectrum of clinical, epidemiological, experimental, and technological factors to inspire front-line practices and shape critical thinking.

The aim of this Special Issue is to collate articles that will contribute scientifically to hypertension research in primary care. We encourage outstanding and timely work that bridges the boundaries between various disciplines involved in hypertension management. Both original research and review articles are welcome.

Potential topics include but are not limited to the following:

• Epidemiology of high blood pressure and coexisting long-term conditions
• Primary care strategies to facilitate prevention, treatment, and care
• Health care burdens from the perspectives of economics and sociology
• Patient safety and clinical efficacy in managing hypertension and concomitant cardiovascular disease risk
• Innovative health technology assessment to inform clinical practice
• Engagement, behavioural support, and patient-reported outcome measures
• Role of unhealthy lifestyles in the progression of cardiovascular diseases
• Predictive, preventive, and personalised medicine in cardiovascular health
• Cardiovascular engineering research inspiring device-based interventions
• Optimised antihypertensive therapies for patients with multimorbidity
• New challenges and strategies for blood pressure management