BioMed Research International

Mitochondria and Cancer


Publishing date
30 Nov 2012
Status
Published
Submission deadline
13 Jul 2012

Lead Editor

1Mitomics Inc. Thunder Bay, ON, Canada

2Dermatological Sciences, Newcastle University, Newcastle Upon Tyne UK

3Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada


Mitochondria and Cancer

Description

Commonly known as the power house of the cell, the mitochondrion and its modest genome have become power players in multiple biological disciplines in the posthuman genome era, including an increasing role in oncogenesis. As a mediator of multiple biochemical pathways, this organelle has emerged as a major biological participant in malignant transformation and tumor behavior. In particular, the observation of altered mitochondrial respiration in the 1920s, known as the Warburg effect, is a characteristic of malignant transformation. Further, the mitochondrial genome is replete with mitochondrial genome mutations in nearly all solid tumors. This suggests an early clinical detection opportunity because of the accelerated mutation rate and high copy number of mitochondrial DNA in tissues and biofluids. Moreover, it has been widely discussed that mitochondria are ideal targets for chemoprevention and/or therapeutic intervention of cancer.

We invite investigators to contribute original research articles, as well as reviews, that will inform, instruct, and provide an overview of the latest theoretical and bench top results related to the mitochondrion and its biochemical role in cancer. Potential topics include, but are not limited to:

  • Metabolic pathway traffic and mitochondrial mediation
  • Nuclear mitochondrial interactions
  • Role of mitochondrial genome alterations in oncogenesis and tumor metastasis
  • Mitochondrial energy flow, biochemistry, Warburg effect, and tumorigenesis
  • Mitochondrial mutations as biomarkers and early indicators of malignant transformation and tumor progression
  • Use of high-copy mitochondrial biomarkers for detection of occult malignancies using tissues and biofluids
  • Mitochondria and cancerization field effect.
  • Directed cancer therapy targeting Mitochondria
  • Diagnostic utility of metabolic pathways

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jbb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 763703
  • - Editorial

Mitochondria and Cancer

Ryan Parr | Andrew Harbottle | ... | Gurmit Singh
  • Special Issue
  • - Volume 2013
  • - Article ID 612369
  • - Review Article

Mitochondria and Cancer: Past, Present, and Future

M. L. Verschoor | R. Ungard | ... | G. Singh
  • Special Issue
  • - Volume 2013
  • - Article ID 157547
  • - Research Article

Simultaneous Quantification of Mitochondrial DNA Damage and Copy Number in Circulating Blood: A Sensitive Approach to Systemic Oxidative Stress

Sam W. Chan | Simone Chevalier | ... | Junjian Z. Chen
  • Special Issue
  • - Volume 2013
  • - Article ID 239257
  • - Research Article

An Inherited Heteroplasmic Mutation in Mitochondrial Gene COI in a Patient with Prostate Cancer Alters Reactive Oxygen, Reactive Nitrogen and Proliferation

Rebecca S. Arnold | Qian Sun | ... | John A. Petros
  • Special Issue
  • - Volume 2013
  • - Article ID 825065
  • - Review Article

Oxidative Stress Induces Mitochondrial DNA Damage and Cytotoxicity through Independent Mechanisms in Human Cancer Cells

Yue Han | Junjian Z. Chen
  • Special Issue
  • - Volume 2013
  • - Article ID 379438
  • - Research Article

Paired Ductal Carcinoma In Situ and Invasive Breast Cancer Lesions in the D-Loop of the Mitochondrial Genome Indicate a Cancerization Field Effect

Andrea Maggrah | Kerry Robinson | ... | Ryan Parr
  • Special Issue
  • - Volume 2013
  • - Article ID 868131
  • - Research Article

p55PIK Transcriptionally Activated by MZF1 Promotes Colorectal Cancer Cell Proliferation

Yu Deng | Jing Wang | ... | Junbo Hu
BioMed Research International
 Journal metrics
Acceptance rate30%
Submission to final decision81 days
Acceptance to publication43 days
CiteScore2.410
Impact Factor2.197
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