After decades of little to no change in outcome, we are now seeing improvement in the survival for glioblastoma multiforme (GBM) patients. Whether this is due to improved imaging, surgery, radiation, adjuvant therapy, or delivery methods is uncertain. What is known is that the field is moving in the right direction. In this issue, we will analyze those advances and their opportunities as well as their limitations. Hopefully, this issue will stimulate new understanding and cross-discipline collaborations that will change the outlook for this disease.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to provide better care and improved outcomes for patients with GBM. We are particularly interested in articles that describe new modalities of treatment, how genetic characterization may aid in diagnosis and optimizing treatment options, the role angiogenesis plays in the intracranial tumor microenvironment, how immunotherapy might be utilized to improve outcomes, and novel treatments that might be considered. Potential topics include, but are not limited to:

• Molecular targets for diagnosis and treatment
• Advances in immunotherapy for intracranial tumors
• New imaging modalities and their correlation with molecular biology
• Role of angiogenesis in GBM
• Classical treatment options as well as recent novel therapeutic modalities
• The role of cancer stem cells in GBM malignancy
• Latest technologies and treatment options for GBM
• Recent developments in nanotechnology and drug delivery
• New surgical and radiotherapy tools and techniques
• Spine cancer

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/neurology/cfn/ according to the following timetable: