BioMed Research International

Diagnostic, Prognostic, and Predictive Molecular Biomarkers and the Utility of Molecular Imaging in Common Gastrointestinal Tumors


Publishing date
08 May 2015
Status
Published
Submission deadline
19 Dec 2014

1VCU Medical Center, Richmond, USA

2University of Arkansas for Medical Sciences, Little Rock, USA


Diagnostic, Prognostic, and Predictive Molecular Biomarkers and the Utility of Molecular Imaging in Common Gastrointestinal Tumors

Description

The past decade has witnessed an increasing utility and availability of molecular tests and molecular imaging for diagnostic, prognostic, and predictive purposes in oncology. The sheer number of available tests and emergence of new technology-like next generation sequencing can be overwhelming for practicing pathologists/physicians. Understanding the utility and limitations of these molecular tests and molecular imaging has become critical to enable physicians to maximize the utility of these tests, minimize costs by ordering appropriate tests, and also educate patients on test utility and limitations. One area where there is increasing utility for molecular studies is in gastrointestinal/pancreatobiliary tumors.

This special issue will focus on the applications of molecular tests and molecular imaging in selected gastrointestinal/pancreatobiliary tumors with emphasis on methodology, interpretation, interpretive pitfalls, test limitations, clinical utility, and quality. Articles addressing emerging technologies as well as those on more traditional readily accessible methods are welcome.

Potential topics include, but are not limited to:

  • Carcinomas:
    • Overview of common molecular pathways gastrointestinal/pancreatobiliary cancers
    • The utility of molecular studies in targeted therapy of gastrointestinal/pancreatobiliary cancers
    • Mismatch repair protein/microsatellite instability studies in colorectal carcinomas
    • Molecular tests in other selected hereditary cancer syndromes
  • Spindle cell tumors:
    • Overview of gastrointestinal spindle cell neoplasms
    • The utility of molecular tests in the diagnosis and prognosis of gastrointestinal spindle cell neoplasms
    • Therapeutic utility of molecular tests/biomarkers in selected spindle cell tumors
  • Gastrointestinal lymphomas:
    • Overview of gastrointestinal lymphomas
    • The utility of molecular studies in the diagnosis of gastrointestinal lymphoproliferative disorders
    • The prognostic and therapeutic utility of molecular studies in gastrointestinal lymphomas
  • Overview of the utility of molecular imaging in gastrointestinal/pancreatobiliary cancers:
    • Correlation of pathway-directed molecular imaging and genomic science
    • Application of molecular image-guided personalized therapy

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 890805
  • - Editorial

Diagnostic, Prognostic, and Predictive Molecular Biomarkers and the Utility of Molecular Imaging in Common Gastrointestinal Tumors

Michael O. Idowu | Jennifer Laudadio | Kathryn Rizzo
  • Special Issue
  • - Volume 2015
  • - Article ID 681653
  • - Research Article

Molecular Profiling-Selected Therapy for Treatment of Advanced Pancreaticobiliary Cancer: A Retrospective Multicenter Study

Ron Epelbaum | Einat Shacham-Shmueli | ... | Ravit Geva
  • Special Issue
  • - Volume 2015
  • - Article ID 593572
  • - Research Article

Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma

Alan R. Penheiter | Sibel Erdogan | ... | Stephanie K. Carlson
  • Special Issue
  • - Volume 2015
  • - Article ID 185404
  • - Research Article

Lack of Association between Membrane-Type 1 Matrix Metalloproteinase Expression and Clinically Relevant Molecular or Morphologic Tumor Characteristics at the Leading Edge of Invasive Colorectal Carcinoma

Annette Arndt | Klaus Kraft | ... | Konrad Steinestel
  • Special Issue
  • - Volume 2015
  • - Article ID 670121
  • - Review Article

Endoscopic Raman Spectroscopy for Molecular Fingerprinting of Gastric Cancer: Principle to Implementation

Hyung Hun Kim
  • Special Issue
  • - Volume 2015
  • - Article ID 149014
  • - Review Article

Colorectal Cancer Biomarkers: Where Are We Now?

Maria Gonzalez-Pons | Marcia Cruz-Correa
BioMed Research International
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Acceptance rate31%
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Acceptance to publication52 days
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