BioMed Research International

The Roads to Mitochondrial Dysfunction


Publishing date
24 Oct 2014
Status
Published
Submission deadline
06 Jun 2014

1Faculdade de Desenvolvimento do Rio Grande do Sul, Rua Luiz Afonso, 84, 90050-310 Porto Alegre, RS, Brazil

2Department of Biotechnology, Periyar University, Salem, Tamil Nadu 636011, India

3Department of Physiology, University of Split School of Medicine, Soltanska 2, 21000 Split, Croatia


The Roads to Mitochondrial Dysfunction

Description

The main role of mitochondria is to produce adenosine triphosphate (ATP) through the oxidative phosphorylation system for maintenance of normal cellular function. However, these organelles participate in several biochemical pathways other than ATP production, as for instance gluconeogenesis in liver and kidney, glyceroneogenesis in adipose tissue, and urea cycle in liver, to cite a few. Furthermore, mitochondria play a pivotal role in cell fate, since proapoptotic signals may be released from mitochondria in some circumstances. Also, it has been demonstrated that mitochondrial physiology may be altered due to extracellular signals, as for example, the level of neurotrophins, hormones, nutrients, and pharmacological toxicants in both macro- and microenvironments. Then, mitochondrial function changes as the necessities of the cells, but some molecules may induce mitochondrial dysfunction by interacting with the organelle and causing a decrease in ATP synthesis, an increase in reactive species production (e.g., free radicals), and/or the release of proapoptotic factors, for example.

We are particularly interested in manuscripts that report the results of investigations regarding the role of mitochondrial dysfunction in neurodegenerative diseases, proinflammatory processes (sepsis, trauma, infection, burn, and others), nutritional abnormalities, tumors, and disturbances affecting hepatic, renal, cardiovascular, immune, and gastrointestinal systems. Furthermore, manuscripts dealing with the role of bioactive molecules, pharmacological agents, and toxicants on mitochondrial function and dysfunction are welcome. Potential topics include, but are not limited to:

  • Mitochondrial dysfunction and related signaling pathways
  • Mitochondrial reactive species production (including free radicals) and antioxidant defenses
  • Alterations in mitochondrial structure, metabolism, and/or physiology
  • Interaction of mitochondria with other organelles
  • Bioactive molecules and mitochondrial dysfunction
  • Methods to access mitochondrial function
  • Future strategies to treat mitochondrial dysfunction

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/cell.biology/rmd/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 831490
  • - Research Article

The Roads to Mitochondrial Dysfunction in a Rat Model of Posttraumatic Syringomyelia

Zhiqiang Hu | Jian Tu
  • Special Issue
  • - Volume 2015
  • - Article ID 235370
  • - Editorial

The Roads to Mitochondrial Dysfunction

Marcos Roberto de Oliveira | Namasivayam Elangovan | ... | Ancha Baranova
  • Special Issue
  • - Volume 2015
  • - Article ID 353074
  • - Research Article

Dose Response of Endotoxin on Hepatocyte and Muscle Mitochondrial Respiration In Vitro

Victor Jeger | Sebastian Brandt | ... | Siamak Djafarzadeh
  • Special Issue
  • - Volume 2014
  • - Article ID 735106
  • - Research Article

Silencing of Plasma Membrane Ca2+-ATPase Isoforms 2 and 3 Impairs Energy Metabolism in Differentiating PC12 Cells

Tomasz Boczek | Malwina Lisek | ... | Ludmila Zylinska
  • Special Issue
  • - Volume 2014
  • - Article ID 234370
  • - Review Article

Bcl-2 Family Proteins Are Involved in the Signal Crosstalk between Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Tumor Chemotherapy Resistance

Jing Su | Lei Zhou | ... | Lian-kun Sun
  • Special Issue
  • - Volume 2014
  • - Article ID 472459
  • - Review Article

Fatty Acids in Energy Metabolism of the Central Nervous System

Alexander Panov | Zulfiya Orynbayeva | ... | Vyacheslav Lyakhovich
  • Special Issue
  • - Volume 2014
  • - Article ID 632986
  • - Research Article

Impairment of Electron Transfer Chain Induced by Acute Carnosine Administration in Skeletal Muscle of Young Rats

José Roberto Macarini | Soliany Grassi Maravai | ... | Gustavo Costa Ferreira
  • Special Issue
  • - Volume 2014
  • - Article ID 238463
  • - Review Article

Mitochondrial Aging and Age-Related Dysfunction of Mitochondria

Dimitry A. Chistiakov | Igor A. Sobenin | ... | Yuri V. Bobryshev
  • Special Issue
  • - Volume 2014
  • - Article ID 292017
  • - Review Article

Quantitative Assessment of Heteroplasmy of Mitochondrial Genome: Perspectives in Diagnostics and Methodological Pitfalls

Igor A. Sobenin | Konstantin Y. Mitrofanov | ... | Alexander N. Orekhov
BioMed Research International
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Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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