transcript transpos element interspers genom control complex interact between regulatori element host factor howev same regulatori element may occasion use transcript host gene one exampl human retrotransposon which contain antisens promot asp drive transcript adjac gene yield chimer transcript have character 49 chimer mrnas correspond sens antisens strand human gene here show asp capabl function altern promot give rise chimer transcript whose code region ident orf mrna follow gene kiaa1797 clcn5 slco1a2 furthermor case activ asp tissuespecif may expand express pattern respect gene the activ asp tissuespecif also case where asp produc antisens rnas complementari col11a1 boll mrnas simultan assess activ asps multipl loci reveal presenc aspderiv transcript all human tissu examin also demonstr asp can act promot vivo predict has heterogen transcript initi site our data suggest aspdriven transcript may increas transcript flexibl sever human gene

Kert Mätlik

Kaja Redik

Mart Speek

L1 Antisense Promoter Drives Tissue-Specific Transcription
of Human Genes

line1 retrotransposon constitut most success famili retroel mammal account much 20 mammalian dna element can found all genom region far more abund atrich genepoor lowrecombin region genom addit sex chromosom some gene seem disproportion enrich element insertion bias select process can both account bias distribut element element appear insert random genom insert bias can least partial explain genom distribut the contrast distribut alu element suggest postinsert process play major role shape distribut the most like mechan loss recent integr element deleteri negat select either becaus disrupt gene function abil mediat ectop recombin comparison retent element becaus some posit effect limit small fraction genom understand respect import insert bias select requir better knowledg insert mechan dynam insert popul

Todd  Graham

Stephane  Boissinot

The Genomic Distribution of L1 Elements: The Role of Insertion Bias and Natural Selection

Nina Luning Prak

Abdelali  Haoudi

LINE-1 Retrotransposition: Impact on Genome  Stabilityand Diversity and Human Disease

the hypothesi rna interfer constrain mobil seem inher reason mobil can danger rna presum target rnai serv critic retrotransposit intermedi despit it plausibl proof hypothesi has been difficult obtain studi attempt link retrotransposit frequenc alter rnai activ have been hamper long time requir measur retrotransposit frequenc pleiotrop toxic effect alter rnai over similar time period possibl other cellular machineri may contribut regul l1s another problem common use report cassett may serv substrat rnai here review l1rnai hypothesi describ genet assay modifi report cassett detect approxim 4 time more insert than convent retrotransposit assay

Shane R. Horman

Petr Svoboda

Eline T. Luning Prak

The Potential Regulation of L1 Mobility by RNA Interference

there longstand evid xchromosom inactiv xci travel less success autosom than xchromosom chromatin the interspers repeat element line1s l1s have been suggest candid booster which promot spread xci xchromosom the present paper review current evid concern possibl role l1s xci recent evid accru from human genom sequenc project other sourc confirm mammalian xchromosom inde rich l1s except region where mani gene escap xci the densiti l1s highest evolutionarili oldest region recent work autosom transloc human mous suggest failur stabil xci autosom materi gene reactiv resist autosom gene origin silenc exclud the accumul l1s xchromosom may have result from reduc recombin late replic whether l1s part mechan xci result remain enigmat

Mary F. Lyon

Do LINEs Have a Role in X-Chromosome Inactivation?

barbara mcclintock first suggest transposon sourc genom instabl genotox stress assist mobil the generat doublestrand dna break dsbs sever form genotox stress threaten integr genom activ cell cycl checkpoint some case caus cell death appli mcclintock stress hypothesi human retrotransposon most activ autonom mobil element modern day human genom mobil dsbs here evid transpos element particular retrotransposon mobil genotox stress review set dsb format mobil may affect chang substrat integr dna repair machineri element itself the review conclud discuss potenti consequ mobil set genotox stress

Evan A. Farkash

DNA Damage and L1 Retrotransposition

line1 element most abund autonom nonltr retrotransposon human genom have recent perform metaanalysi endonucleasemedi retrotransposit event caus human genet diseas have extend studi focus two key issu name mutat detect bias multipl mechan target gene disrupt our analysi suggest wherea ascertain bias may have general milit against detect autosom l1mediat insert autosom direct insert could have been disproportion overlook owe unusu larg size our analysi has also indic mechan under function disrupt target gene l1mediat retrotransposit event like depend sever differ factor type insert direct tran driven alu sva precis locat insert sequenc within target gene region length insert sequenc possibl also orient

Jian-Min Chen

Claude Férec

David N. Cooper

LINE-1 Endonuclease-Dependent Retrotranspositional Events Causing Human Genetic Disease: Mutation Detection Bias and Multiple Mechanisms of Target Gene Disruption

chronic feed methyldonor methionin cholin folic acid vitamin b12 defici diet induc hepatocellular carcinoma format rat previous studi have shown promot cpg island various cancerrel gene aberr methyl model moreov global genom methyldonordefici diet fed rat contain lesser amount 5methylcytosin than control liver specul more than 90 all 5methylcytosin lie within cpg island transposon includ long short interspers nucleotid element line sine consid 5methylcytosin line1 limit abil retrotransposon activ transcrib therefor extent hypomethyl line1 could surrog marker aberr methyl other tumorrel gene well genom instabl addition line1 methyl status has been shown good indic genomewid methyl studi determin cytosin methyl status line1 repetit sequenc rat fed cholinedefici diet various durat compar rat fed cholinesuffici diet the methyl status line1 assess combin bisulfit restrict analysi cobra method where amount bisulfitemodifi rsaicleav dna quantifi use gel electrophoresi progress hypomethyl observ line1 liver function feed time amount cytosin total cytosin methyl unmethyl increas from 111 1 week 193 56 week wherea control liver increas from 92 129 hypomethyl tumor tissu slight higher 6 than nontumor surround tissu the present result also indic age factor influenc extent cytosin methyl

Kiyoshi Asada

Yashige Kotake

Rumiko Asada

Deborah Saunders

Robert H. Broyles

Rheal A. Towner

Hiroshi Fukui

Robert A. Floyd

LINE-1 Hypomethylation in a Choline-Deficiency-Induced  Liver Cancer in Rats: Dependence on Feeding Period

line1 autonom nonltr retrotransposon mammal retrotransposit requir function two l1encod polypeptid orf1p orf2p ear recognit region homolog between predict amino acid sequenc orf2 known endonucleas revers transcriptas enzym led testabl hypothes regard function orf2p retrotransposit predict orf2p has been demonstr have both endonucleas revers transcriptas activ contrast homolog known function have contribut our understand function orf1p dure retrotransposit nevertheless signific advanc have been made now know orf1p highaffin rnabind protein form ribonucleoprotein particl togeth rna furthermor orf1p nucleic acid chaperon nucleic acid chaperon activ requir retrotransposit

Sandra L. Martin

The ORF1 Protein Encoded by LINE-1: Structure and Function During L1 Retrotransposition

retrotransposon like silenc somat cell varieti mechan act differ level protect mechan includ dna methyl packag inact chromatin suppress transcript prevent recombin potenti support cytidin deaminas edit rna furthermor dna strand break aris dure attempt retrotransposit ought activ cellular checkpoint activ outsid immunoprivileg site may elicit immun respons number observ indic sequenc nevertheless becom reactiv human cancer promin methyl sequenc diminish mani cancer type fulllength rnas becom detect although strong express restrict germ cell cancer element have been found enrich site illegitim recombin mani cancer theori lack repress cancer might caus transcript deregul insert mutat dna break increas frequenc recombin contribut genom disorgan express chang chromosom instabl there howev littl evid effect occur gross scale human cancer rather rule repress onli part allevi unfortun mani techniqu common use investig genet epigenet alter cancer cell well suit detect subtl effect elicit partial reactiv retroel like which present abund heterogen copi therefor effect sequenc exert local chromatin structur transcript regul individu gene chromosom fragil need more close investig normal cancer cell

Wolfgang A. Schulz

L1 Retrotransposons in Human Cancers

About this journal

BioMed Research International publishes original research articles, review articles, and clinical studies covering a wide range of subjects within the biomedical sciences. The journal will accept both basic and translational research.

Journal profile

Meet the editorial board

BioMed Research International maintains an Editorial Board of practicing researchers from around the world, to ensure manuscripts are handled by editors who are experts in the field of study.

Editor spotlight

Submit to Special Issue

We currently have a number of Special Issues open for submission. Special Issues highlight emerging areas of research within a field, or provide a venue for a deeper investigation into an existing research area.

Special Issues

Author guidelines

Editorial board

Databases and indexing

BioMed Research International

This Issue is now open for submissions.
Papers are published upon acceptance, regardless of the Special Issue publication date.

BioMed Research International

LINE-1 Retrotransposition: Impact on Genome Stability and Diversity and Human Disease

LINE-1 Retrotransposition: Impact on Genome Stability and Diversity and Human Disease

Articles

L1 Antisense Promoter Drives Tissue-Specific Transcription of Human Genes

The Genomic Distribution of L1 Elements: The Role of Insertion Bias and Natural Selection

LINE-1 Retrotransposition: Impact on Genome Stability and Diversity and Human Disease

The Potential Regulation of L1 Mobility by RNA Interference

Do LINEs Have a Role in X-Chromosome Inactivation?

DNA Damage and L1 Retrotransposition

LINE-1 Endonuclease-Dependent Retrotranspositional Events Causing Human Genetic Disease: Mutation Detection Bias and Multiple Mechanisms of Target Gene Disruption

LINE-1 Hypomethylation in a Choline-Deficiency-Induced Liver Cancer in Rats: Dependence on Feeding Period

The ORF1 Protein Encoded by LINE-1: Structure and Function During L1 Retrotransposition

L1 Retrotransposons in Human Cancers