BioMed Research International

Signal Transduction and Regulation: Insights into Evolution


Status
Published

Lead Editor

1Harvard Medical School, Boston, USA

2Huazhong University of Science and Technology, Wuhan, China

3Massachusetts Institute of Technology, Cambridge, USA


Signal Transduction and Regulation: Insights into Evolution

Description

Recent advances in modern molecular technology and next-generation sequencing platform have brought in enormous insights into evolution. Although challenges remain, evolutionary research now enters a new era and becomes a hybrid discipline encompassing the fields of molecular biology, genetics and genomics, metabolomics, neuroscience, structural and chemical biology, bioinformatics, proteomics, pharmacology, statistics, and computational biology. The common bond or theme that unifies the various fields is the need to reveal complex genotype-phenotype relationships and their dynamic regulations, attempting to understand the diversifying functionality in life and ultimately find the underlying causes and effective means of treating disease.

The future evolution researchers will need to be well-versed in each of these fields and have the appropriate background to leverage the biological, clinical, and computational resources necessary to understand their data and track dynamic evolution. The communication among these specialty disciplines, acting in unison, will be critical as we strive to uncover answers underlying the complex and often puzzling molecular events in evolution. Articles should focus on molecular advances with evolutionary insights.

Potential topics include, but are not limited to:

  • Evolution of signal transduction networks in eukaryotes
  • Evolution of gene regulatory circuits across eukaryotic kingdoms
  • Evolution of molecular interactions and rewiring in disease
  • Environmental selection and adaptive evolution
  • Origin of genes and evolution of phenotypes
  • Evolution of genetic variants and protein sequences
  • De novo genome assembly and gene birth
  • Evolution of protein structure and molecular function
  • Splice variations and novel gene function derivation
  • Accelerated next-generation sequencing technologies and evolutionary applications
  • Environmental regulation and epigenetic modulation
  • Posttranslational modification and protein plasticity
  • Evolution of essential cellular functions
  • Mechanisms of sensory perception and circadian clock across model organisms
  • Phylogenetic analysis and computational molecular profiling
  • Gene expression profiling and evolutionary insights
  • Drug repurposing and personalized medicine in evolution
  • Fundamental mechanisms of neurodegeneration and synapse formation across model organisms
  • Machine learning and integrative approaches for omics-based evolutionary research

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 8604245
  • - Editorial

Signal Transduction and Regulation: Insights into Evolution

Song Yi | Sidi Chen | ... | Nidhi Sahni
  • Special Issue
  • - Volume 2016
  • - Article ID 6186281
  • - Review Article

Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks

Shengda Lin | Yi A. Yin | ... | Song Yi
  • Special Issue
  • - Volume 2016
  • - Article ID 4658506
  • - Research Article

Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks

Sandip Chakraborty | David Alvarez-Ponce
  • Special Issue
  • - Volume 2016
  • - Article ID 7281732
  • - Research Article

Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder

Ubadah Sabbagh | Saman Mullegama | Gerald J. Wyckoff
  • Special Issue
  • - Volume 2016
  • - Article ID 2456062
  • - Research Article

Neurotrophin, p75, and Trk Signaling Module in the Developing Nervous System of the Marine Annelid Platynereis dumerilii

Antonella Lauri | Paola Bertucci | Detlev Arendt
  • Special Issue
  • - Volume 2016
  • - Article ID 5052369
  • - Research Article

A CRISPR-Based Toolbox for Studying T Cell Signal Transduction

Shen Chi | Arthur Weiss | Haopeng Wang
  • Special Issue
  • - Volume 2015
  • - Article ID 792904
  • - Research Article

Computational Analysis of the Binding Specificities of PH Domains

Zhi Jiang | Zhongjie Liang | ... | Guang Hu
  • Special Issue
  • - Volume 2015
  • - Article ID 780519
  • - Research Article

SimFuse: A Novel Fusion Simulator for RNA Sequencing (RNA-Seq) Data

Yuxiang Tan | Yann Tambouret | Stefano Monti
  • Special Issue
  • - Volume 2015
  • - Article ID 187809
  • - Review Article

Circadian Control of Global Transcription

Shujing Li | Luoying Zhang
  • Special Issue
  • - Volume 2015
  • - Article ID 510319
  • - Review Article

Roles of Hsp70s in Stress Responses of Microorganisms, Plants, and Animals

Anmin Yu | Ping Li | ... | Li Liu
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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