Plasminogen Receptors
1Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
2Department of Medicine, University of California, San Diego and Veterans Administration San Diego Healthcare System, San Diego, CA 92093, USA
3Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA
4Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada B3H 4R2
Plasminogen Receptors
Description
Plasminogen receptors are very broadly distributed on both prokaryotic and eukaryotic cells. Plasminogen receptors function to promote the activation of the circulating zymogen, plasminogen, to the broad-spectrum protease, plasmin. In addition to fibrinolysis, cell-bound plasmin has the capacity to process proteins of the extracellular matrix to enable physiological and pathophysiological processes requiring cell migration (including inflammation, tissue remodeling, wound healing, tumor cell invasion and metastasis, skeletal myogenesis, and neurite outgrowth) as well as to process prohormones. Recent developments with knockout mice, transfection studies, specific knockdown, and specific antibody blockade have identified new functions for plasminogen receptors.
We are interested in articles that identify physiologic and pathologic roles of specific plasminogen receptors. Potential topics include, but are not limited to:
- The role of plasminogen receptors in physiological and pathophysiological processes
- Mechanisms of regulation of expression of plasminogen receptors
- The interplay between plasminogen receptors and plasminogen activator receptors
- Plasminogen receptors as a component of the proteolytic hub
- The role of plasminogen receptors in plasmin-dependent regulation of other proteases
- Knockout mouse models of plasminogen receptors
- Structure-function studies
- Bacterial plasminogen receptors
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