Neurovascular disorders are a group of pathological conditions that result from neurovascular injury. Neurovascular disorders include cerebral ischaemia, intracerebral haemorrhage, subarachnoid haemorrhage, venous sinus thrombosis, carotid disease, cerebral small vessel disease, and vascular dementia, among others. Although there is now a greater understanding of both the genetic links and the basic mechanisms behind the pathophysiology of neurovascular diseases, the exact mechanisms are still unclear, therefore there is an urgent to find significant therapeutic targets.

The determination of biomarkers plays an important role in the prevention, treatment, and improvement of the prognosis of diseases, and provides new ideas for further revealing their causes and mechanisms. Changes in tissue fluids such as blood or cerebrospinal fluid reflect changes in brain parenchymal structure or function to some extent and are key clues in exploring the aetiology and mechanism of disease. Changes in biomarkers in different periods of the disease reflect different types of disease or different courses of the same disease. It is of great significance for accurate diagnosis and precise treatment of diseases. For some specific neurological diseases, such as vascular dementia, CADASIL, stroke, epilepsy, cerebral small vessel disease, vascular cognitive impairment, and autism, there is still a lack of biomarkers with high sensitivity and specificity. The discovery of high-efficiency biomarkers may partially replace some of the current gold standards for invasive diagnosis, which will usher in a new era of non-invasive or low-invasive precision and individualised treatment.

Therefore, this Special Issue aims to collect novel articles investigating the clinical application of biomarkers for neurovascular disorders, and innovation and developments in biomarkers in these disorders. We also aim to gather papers probing the mechanisms underlying neurovascular disorders, including, but not limited to, Alzheimer’s disease, ischaemic stroke, cerebral small vessel disease, intracerebral haemorrhage, subarachnoid haemorrhage, venous sinus thrombosis, carotid disease, and vascular dementia. Both original research and review articles are welcomed.

Potential topics include but are not limited to the following:

• Peripheral blood or cerebrospinal fluid biomarkers for neurovascular disorders
• Imaging markers for neurovascular disorders
• Research on pathogenic genes in neurovascular disorders
• Neurovascular disorders and disorders of diet, exercise, and intestinal flora
• Bioinformatic analysis of the prevention, treatment, and prognosis of neurovascular disorders
• Cross-study of neurovascular disorders and other system diseases
• Clinical and basic research in the progress of neurovascular disorders
• Neurovascular disorders and cognitive impairment
• Neurovascular disorders and inflammation
• Potential targets and drug treatments of neurovascular disorders