BioMed Research International

Plant-Derived Drugs as an Alternative Therapeutic Option for Cancer Treatment


Publishing date
01 May 2020
Status
Closed
Submission deadline
27 Dec 2019

Lead Editor

1University of Dhaka, Dhaka, Bangladesh

2University of Chittagong, Chittagong, Bangladesh

3UCLA, Los Angeles, USA

4Zhejiang Academy of Medical Sciences, Zhejiang, China

This issue is now closed for submissions.
More articles will be published in the near future.

Plant-Derived Drugs as an Alternative Therapeutic Option for Cancer Treatment

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Despite continued research efforts and expense, cancer remains an aggressive killer and is one of the leading causes of death worldwide, representing one of the biggest health-care issues for the human race. During the last decade, novel synthetic anticancer agents in current clinical use have not been as successful as expected in defending against cancer. Cancer is comprised of a group of various diseases and involves uncontrolled multiplication and division of abnormal cells which can form malignant growths and divert signaling pathways. Treatment of cancer cells with synthetic chemotherapeutic drugs, which have their own intrinsic adverse effects, affects the regulatory functions of noncancerous cells as well. Toxicities such as myelotoxicity, cardiotoxicity, nephrotoxicity, pulmonary toxicity, cutaneous toxicity, and vasospasticity have been well documented as the major adverse reactions for common anticancer drugs such as 5-fluorouracil, doxorubicin, and bleomycin. There is therefore a need to develop new, effective, safer, and more affordable anticancer drugs from alternative sources.

Plant products as a replacement for synthetic chemopreventive agents may provide a valuable approach for developing novel chemical entities to defend against cancer through the potential of bioactive plant secondary metabolites, many of which—such as vinblastine, vincristine, taxol, and camptothecin—have already been highlighted as having potential antitumor properties. There is also increasing evidence for the potential of plant-derived compounds to act as inhibitors of various stages of tumorigenesis and associated inflammatory processes, underlining the importance of these products in cancer prevention. In addition to this, phytochemicals are considered as suitable candidates for anticancer drug development due to their pleiotropic actions on target sites with multiple outcomes. Research into plant products may, therefore, contribute to the development of effective and novel alternative therapeutics in the search for safer, eco-friendly, low-cost, fast, and cancer treatment drugs.

This special issue aims to collect original research and review articles regarding research into plant-derived drugs in cancer prevention.

Potential topics include but are not limited to the following:

  • Prospects and paradigms of plant-based drugs-mediated cancer treatment
  • Ways and options to modulate the signaling pathways by plants
  • Drug-receptor interaction efficiencies in anticancer drug discovery
  • Biomarkers targeted for plant-derived anticancer drug development
  • Cell-line studies in developing cancer treatments
  • Functional foods for suppressing cancer cells
  • Alternative plant-based therapies to cure various cancers
  • Intercontinental variations in alternative therapies for cancer prevention

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 8716927
  • - Research Article

Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach

Ramalingam Srinivasan | Arumugam Aruna | ... | Devarajan Natarajan
  • Special Issue
  • - Volume 2020
  • - Article ID 8602879
  • - Review Article

Phytochemicals as Potential Anticancer Drugs: Time to Ponder Nature’s Bounty

Mohammad Arif Ashraf
  • Special Issue
  • - Volume 2020
  • - Article ID 1340153
  • - Review Article

Herbal Active Ingredients: An Emerging Potential for the Prevention and Treatment of Papillary Thyroid Carcinoma

Yang Yang | Qin Chen | ... | Chen-Huan Yu
  • Special Issue
  • - Volume 2019
  • - Article ID 3480569
  • - Research Article

Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α

Zarith Nameyrra Md Nesran | Nurul Husna Shafie | ... | Siti Farah Md Tohid
  • Special Issue
  • - Volume 2019
  • - Article ID 9083068
  • - Review Article

The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment

Qiushuang Li | Yang Xiong | ... | Zhiqiang Yan
  • Special Issue
  • - Volume 2019
  • - Article ID 4836378
  • - Research Article

In Vitro Evaluation of the Potential Use of Propolis as a Multitarget Therapeutic Product: Physicochemical Properties, Chemical Composition, and Immunomodulatory, Antibacterial, and Anticancer Properties

Soumaya Touzani | Walaa Embaslat | ... | Bashar Saad
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision81 days
Acceptance to publication53 days
CiteScore2.410
Impact Factor2.197
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