BioMed Research International

Contribution of Liver Nonparenchymal Cells to Hepatic Fibrosis: Interactions with the Local Microenvironment


Status
Published

Lead Editor

1University of Arkansas, Little Rock, USA

2University of Kansas, Kansas City, USA

3Harvard University, Boston, USA

4University of Queensland, Greenslopes, Australia


Contribution of Liver Nonparenchymal Cells to Hepatic Fibrosis: Interactions with the Local Microenvironment

Description

Hepatic fibrosis is an intrinsic wound healing response to chronic liver injury of various etiologies. This pathologic process is characterized by inflammation, scarring, and vascular remodeling and is mainly driven by a specialized, yet heterogeneous, population of hepatic effector cells known as liver myofibroblasts. Following tissue or cell injury, liver myofibroblasts undergo differentiation to produce matrix components and simultaneously become increasingly sensitive to autocrine and paracrine fibrogenic signals. Although research studies have identified numerous candidate molecules, there is no therapy currently available to prevent and treat hepatic fibrosis in patients. A better understanding of this intricate interplay between liver myofibroblasts and their surrounding microenvironment within the liver is key for the development of innovative molecular tools, useful animal models, and effective treatments for hepatic fibrosis.

We invite authors to submit original research and review articles that seek to define cell-to-cell or cell-to-matrix interactions involving liver myofibroblasts as primary fibrogenic effector cells, or other liver nonparenchymal cells that regulate liver myofibroblast functions in the setting of hepatic fibrosis. We are interested in articles that explore molecular aspects of liver myofibroblast biology in humans and in animal models.

Potential topics include but are not limited to the following:

  • Development and testing of novel and effective antifibrotic therapies
  • Identification of new therapeutic targets in liver myofibroblasts and other liver nonparenchymal cells
  • Identification of biomarkers/correlates of liver fibrosis progression and resolution
  • New cellular and animal models to test and understand liver fibrosis
  • Identifying mechanisms in liver myofibroblasts and other liver nonparenchymal cells promoting disease progression and resolution

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 6824762
  • - Editorial

Contribution of Liver Nonparenchymal Cells to Hepatic Fibrosis: Interactions with the Local Microenvironment

Michel Fausther | Michele T. Pritchard | ... | Kim Bridle
  • Special Issue
  • - Volume 2017
  • - Article ID 4097205
  • - Review Article

SECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis

Vaishaali Natarajan | Edward N. Harris | Srivatsan Kidambi
  • Special Issue
  • - Volume 2016
  • - Article ID 4918798
  • - Review Article

Evidence for a “Pathogenic Triumvirate” in Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease

Lu Jiang | Pingping Fang | ... | Michele T. Pritchard
  • Special Issue
  • - Volume 2016
  • - Article ID 3162670
  • - Review Article

Transitional Remodeling of the Hepatic Extracellular Matrix in Alcohol-Induced Liver Injury

Lauren G. Poole | Gavin E. Arteel
  • Special Issue
  • - Volume 2016
  • - Article ID 5170402
  • - Review Article

Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells

Nancy Magee | An Zou | Yuxia Zhang
  • Special Issue
  • - Volume 2016
  • - Article ID 2646212
  • - Review Article

Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis

Takaoki Saneyasu | Riaz Akhtar | Takao Sakai
  • Special Issue
  • - Volume 2016
  • - Article ID 5309328
  • - Research Article

Aryl Hydrocarbon Receptor Activation by TCDD Modulates Expression of Extracellular Matrix Remodeling Genes during Experimental Liver Fibrosis

Cheri L. Lamb | Giovan N. Cholico | ... | Kristen A. Mitchell
  • Special Issue
  • - Volume 2016
  • - Article ID 8323747
  • - Review Article

Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors

Justin D. Schumacher | Grace L. Guo
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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