Biological mechanism involving bone repair mainly contains both osteoconductivity and osteoinductivity. Most scaffolds for bone tissue engineering demonstrate osteoconductivity, but they lack osteoinductivity to stimulate cell differentiation and bone regeneration, which impedes their wide application.

Scaffolds with osteoinductivity can give these biological signals for proliferation and differentiation of bone marrow mesenchymal stem cells and osteoblast-like cells to promote bone regeneration. Recently, they can be fabricated by loading with drugs, manufacturing special structure, and so on.

To promote communication between researchers of bone tissue engineering, we invite investigators to contribute original research articles as well as review articles that will stimulate continuing efforts to explore scaffolds with osteoinductivity for bone regeneration.

Potential topics include but are not limited to the following:

• Novel biomaterials with osteoinductivity
• Scaffolds with special structure beneficial for osteoinductivity
• Drug-loaded scaffolds with biological signals to promote bone regeneration
• In vitro and in vivo osteogenesis effect of scaffolds with osteoinductivity