Over the last decade, the increasing incidence of severe obesity in postmenopausal women and the continuous aging of the female population led to a renewed attention to the management of endometrial cancer (EC), which now represents the 4th most common neoplasia in developed countries, based on USA data. In particular, surgery remains the cornerstone in the treatment of EC, and after the successful introduction of minimally invasive approaches, the emerging therapeutic frontier is the incorporation of sentinel node biopsy (SNB) into surgical algorithms.

However, at this specific point, several issues still remain to be addressed, such as the safety of SNB in women with high-risk disease, and the role of lymphadenectomy in women with no SN detection, and the management of micrometastatic and isolated tumor cells within the lymph nodes. Furthermore, compelling data are now available supporting non-surgical treatment in both women with morbid obesity and multiple co-morbidities, as well as in young EC patients with pregnancy desire, thus giving new hope to this group of women. Finally, besides the evolutions in the surgical field, a growing role is progressively gaining molecular characterization of this neoplasia, which in the near future will drive the choice among adjuvant treatments, and the counseling regarding prognosis and genetic implications. Therefore, in this intriguing scenario, it is reasonable to hypothesize that we will see a continuous effort toward the tailoring of therapeutic approaches in women with EC, from surgery to chemo and radiation therapy.

This Special Issue aims to collect original research and review articles relating to current studies on the diagnosis and management of endometrial cancer. Researchers are invited to submit articles relating to diagnosis, molecular characterization, surgical, and adjuvant treatment for women with endometrial cancer.

Potential topics include but are not limited to the following:

• Ultrasound and minimally invasive diagnostic approaches
• Sentinel node biopsy promises and pitfalls
• Innovation in endoscopic strategies
• Non-surgical and fertility sparing treatments
• Molecular disease characterization
• Preclinical data for new drugs
• New evidences regarding chemotherapy strategies
• Evolution of indication and approach for radiation therapy
• Definition and management of isolated tumor cells in lymph nodes