One of the most challenging issues in oncology and pathology is that of tumor cell plasticity. This can be examined in vitro or in vivo and can be seen in humans, based on tumor tissues or circulating cells. Cell plasticity encompasses a large spectrum of issues, from pathogenesis of carcinogenesis through to tumor cells invasion and metastasis. Plasticity examination refers to epithelial-mesenchymal transition, mesenchymal-epithelial transition, endothelial-mesenchymal transition, trans- or dedifferentiation, proneural-mesenchymal transition, and any other aberrant behavior of tumor cells.

This special issue aims to collect papers which can be integrated into a common purpose: that of furthering the understanding of the plasticity of tumor cells at different stages of tumor progression. Review articles are welcomed, if they are based on immunohistochemical, molecular, or pathogenic mechanism of cancer cell plasticity.

Potential topics include but are not limited to the following:

• Epithelial-mesenchymal/mesenchymal-epithelial/endothelial-mesenchymal transition within tumor cells and stroma
• Proneural-mesenchymal transition within tumor cells and stroma
• Tumor environment (stromal cells, inflammatory cells roles in tumor behavior)
• New potential biomarkers involved in tumorigenesis and tumor invasion
• Cell plasticity-based targeted therapy of cancer