BioMed Research International

ω-3 PUFAs in the Prevention and Cure of Inflammatory, Degenerative, and Neoplastic Diseases


Publishing date
13 Sep 2013
Status
Published
Submission deadline
26 Apr 2013

1Institute of General Pathology, School of Medicine, Catholic University of Rome, Rome, Italy

2Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan

3Experimental and Clinical Research Center (ECRC) and Division of Hepatology and Gastroenterology (including Metabolic Diseases), Charité - Universitätsmedizin Berlin, Berlin, Germany


ω-3 PUFAs in the Prevention and Cure of Inflammatory, Degenerative, and Neoplastic Diseases

Description

Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are dietary components that have attracted considerable interest for their potential role in the prevention and cure of different chronic diseases (including cardiovascular, inflammatory, degenerative, and neoplastic diseases). It is believed that the beneficial pleiotropic effects of an increased intake of these fatty acids may be related to the suppression of the imbalance between the lack of ω-3 PUFAs consumption and the excess of ω-6 PUFAs existing in most Western diets. Considerable effort has been so far expended to identify the molecular mechanisms underlying the beneficial effects of such small and simple molecules. Such effects have been mainly related to the following: (1) their incorporation into cell membranes phospholipids, where they may substitute the ω-6 PUFA arachidonic acid (AA) and prevent the formation of AA-derived bioactive compounds with proinflammatory and procarcinogen potential. Moreover, they may alter the physical-chemical properties of lipid membrane microdomains (i.e., rafts) in the cells, thus modulating the activities of receptors, enzymes, and carriers located in these molecular “platforms”; (2) their metabolic conversion into highly potent bioactive lipids mediators (resolvins and protectins) showing proresolving and protective action towards inflammation and cell degeneration; (3) their ability to modulate the redox status of the cells, both acting as prooxidants or antioxidants. However, many doubts still exist regarding the optimal and safe dietary doses of ω-PUFAs, as well as concerning the safety and bioavailability of their sources.

We invite investigators to contribute original research and review articles that could help in broadening the current knowledge about the role of ω-PUFAs in human health as well as the molecular mechanisms underlying their beneficial effects. Potential topics include, but are not limited to:

  • ω-3 PUFAs and inflammation
  • ω-3 PUFAs and immune function
  • ω-3 PUFAs and cardiovascular diseases
  • ω-3 PUFAs and the metabolic syndrome
  • ω-3 PUFAs in brain development and diseases
  • ω-3 PUFAs and learning memory
  • ω-3 PUFAs and Alzheimer's disease
  • ω-3 PUFAs and aging
  • ω-3 PUFAs and cancer
  • ω-3 PUFAs and membrane microdomains
  • ω-3 PUFA-derived bioactive lipid mediators
  • ω-3 PUFAs receptors and sensors
  • ω-3 PUFAs and the regulation of gene expression
  • ω-3 PUFAs dietary recommendations
  • Novel sources of ω-3 PUFAs
  • Safety and biodistribution of omega-3 PUFAs

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/biochemistry/puf/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 905986
  • - Editorial

-3 PUFAs in the Prevention and Cure of Inflammatory, Degenerative, and Neoplastic Diseases

Achille Cittadini | Gabriella Calviello | ... | Karsten Weylandt
  • Special Issue
  • - Volume 2013
  • - Article ID 748160
  • - Research Article

Acetylsalicylic Acid Reduces the Severity of Dextran Sodium Sulfate-Induced Colitis and Increases the Formation of Anti-Inflammatory Lipid Mediators

Thomas Köhnke | Beate Gomolka | ... | Karsten H. Weylandt
  • Special Issue
  • - Volume 2013
  • - Article ID 905918
  • - Research Article

Responses of Growth Performance and Proinflammatory Cytokines Expression to Fish Oil Supplementation in Lactation Sows’ and/or Weaned Piglets’ Diets

Jie Luo | Feiruo Huang | ... | Siwen Jiang
  • Special Issue
  • - Volume 2013
  • - Article ID 965417
  • - Review Article

Nutritional Properties of Dietary Omega-3-Enriched Phospholipids

Elisabetta Murru | Sebastiano Banni | Gianfranca Carta
  • Special Issue
  • - Volume 2013
  • - Article ID 368178
  • - Research Article

Omega-3 Fatty Acids Inhibit Tumor Growth in a Rat Model of Bladder Cancer

Belmiro Parada | Flávio Reis | ... | Frederico Teixeira
  • Special Issue
  • - Volume 2013
  • - Article ID 568671
  • - Research Article

The Omega-3 Polyunsaturated Fatty Acid DHA Induces Simultaneous Apoptosis and Autophagy via Mitochondrial ROS-Mediated Akt-mTOR Signaling in Prostate Cancer Cells Expressing Mutant p53

Soyeon Shin | Kaipeng Jing | ... | Kyu Lim
  • Special Issue
  • - Volume 2013
  • - Article ID 310186
  • - Review Article

Dietary ω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer

Nicolò Merendino | Lara Costantini | ... | Francesca Velotti
  • Special Issue
  • - Volume 2013
  • - Article ID 824563
  • - Review Article

Mechanisms of Omega-3 Polyunsaturated Fatty Acids in Prostate Cancer Prevention

Zhennan Gu | Janel Suburu | ... | Yong Q. Chen
  • Special Issue
  • - Volume 2013
  • - Article ID 464921
  • - Review Article

Oxidation of Marine Omega-3 Supplements and Human Health

Benjamin B. Albert | David Cameron-Smith | ... | Wayne S. Cutfield
  • Special Issue
  • - Volume 2013
  • - Article ID 743171
  • - Review Article

Experimental Evidence of -3 Polyunsaturated Fatty Acid Modulation of Inflammatory Cytokines and Bioactive Lipid Mediators: Their Potential Role in Inflammatory, Neurodegenerative, and Neoplastic Diseases

Gabriella Calviello | Hui-Min Su | ... | Achille Cittadini
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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