BioMed Research International

Recent Developments in Kidney Cancer: Biomarkers, Mechanism, and Treatment


Status
Published

Lead Editor

1Huazhong University of Science and Technology, Wuhan, China

2Thomas Jefferson University, Philadelphia, USA

3Harvard University, Cambridge, USA

4China Medical University, Shenyang, China


Recent Developments in Kidney Cancer: Biomarkers, Mechanism, and Treatment

Description

Kidney cancer represents 2-3% of all cancers. Generally, during the last two decades until recently, there has been an annual increase of about 2% in incidence worldwide. The reason for this increase is unknown. Kidney cancer lacks specific symptoms. About half of kidney cancers were diagnosed incidentally by indeliberate imaging examination. The long-term oncological outcomes of kidney caners were closely related with stages. Therefore, the early detection and therapy of kidney cancer is the key point to improve its prognosis. However, there are no satisfactory biomarkers used for early detection, prognosis, and prediction of benefit from therapies, recurrence, or progression of kidney cancer. The basic researches of kidney cancer have given birth to some successful pharmaceutical products such as tyrosine kinase inhibitors (TKI) and m-TOR inhibitors, which have changed the treatment landscape for patients with metastatic kidney cancers. However, the vast majority of treated patients eventually develop progressive disease due to acquired resistance or other reasons. Hence, a better understanding of the mechanisms involved in the pathogenesis of kidney cancer and more effective therapeutic approaches are urgently required. The minimal invasive technologies have been widely used in treatment of kidney cancers. The outcomes of these novel therapeutic technologies are required to be presented to clinical workers in time. We invite investigators to contribute original research articles as well as review articles that focus on identification of new biomarkers, mechanisms, and new developments of minimal invasive technologies underlying kidney cancer.

Potential topics include, but are not limited to:

  • Proteins, microRNA, lncRNA, tumor cells, and DNA in blood and urine as potential biomarkers for early detection, prognosis, and followup of kidney cancer
  • The genetic/epigenetic events leading to the development and progression of kidney cancer
  • New molecularly targeted agents
  • Metabolism of kidney cancer, for example, lipid metabolism in kidney cancer cells
  • Mechanism of resistance to targeted drugs such as TKI and m-TOR inhibitors in kidney cancer
  • Tumor microenvironment in metastatic kidney cancer

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 891045
  • - Research Article

Preoperative Neutrophil-to-Lymphocyte Ratio and Neutrophilia Are Independent Predictors of Recurrence in Patients with Localized Papillary Renal Cell Carcinoma

Jiwei Huang | Douglas M. Dahl | ... | Chin-Lee Wu
  • Special Issue
  • - Volume 2015
  • - Article ID 609549
  • - Clinical Study

Initial Experience of Sorafenib Neoadjuvant Therapy Combined with Retroperitoneoscopy in Treating T2 Large Renal Carcinoma

Chun-hua Lin | He-jia Yuan | ... | Jiahui Wang
  • Special Issue
  • - Volume 2015
  • - Article ID 730390
  • - Research Article

Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma

Maria R. Ambrosio | Bruno J. Rocca | ... | Piero Tosi
  • Special Issue
  • - Volume 2015
  • - Article ID 598134
  • - Research Article

Growth Pattern of Clear Cell Renal Cell Carcinoma in Patients with Delayed Surgical Intervention: Fast Growth Rate Correlates with High Grade and May Result in Poor Prognosis

Lei Zhang | Wenshi Yin | ... | Liqun Zhou
  • Special Issue
  • - Volume 2015
  • - Article ID 802153
  • - Research Article

iTRAQ-Based Quantitative Proteomic Analysis Identified HSC71 as a Novel Serum Biomarker for Renal Cell Carcinoma

Yushi Zhang | Yi Cai | ... | Hanzhong Li
  • Special Issue
  • - Volume 2015
  • - Article ID 163423
  • - Clinical Study

Prognostic Outcomes and Risk Factors for Patients with Renal Cell Carcinoma and Venous Tumor Thrombus after Radical Nephrectomy and Thrombectomy: The Prognostic Significance of Venous Tumor Thrombus Level

Qi Tang | Yi Song | ... | Liqun Zhou
BioMed Research International
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Acceptance rate31%
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Acceptance to publication30 days
CiteScore3.600
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