Recently published articles dealing with Amyotrophic Lateral Sclerosis (ALS) are providing the scientific community a more detailed knowledge of the disease. However, the first link of the neurodegenerative chain that takes places in ALS still remains unknown. Neurodegenerative process in ALS, as in other neurodegenerative diseases, is observed with large accumulations of abnormal proteins, which led to the idea of proteinopathy as a common mechanism of these disorders. The evidence of these proteins can be a significant step in ALS research and numerous studies try to find specific gene/protein targets exclusive for ALS and characteristic of both familial (FALS) and sporadic (SALS) forms in order to facilitate an earlier prognosis and diagnosis of the disease.

We invite authors to submit original and review articles that explore novel prognostic and diagnostic biomarkers of ALS disease. We are particularly interested in articles that can include recent advances in the discovery of molecular biomarkers in animal models and human samples, especially focusing in less explored tissues as well as potential biochemistry and bioinformatic methodology. Furthermore, we will also welcome articles or reviews that focus on other different neurodegenerative diseases, which share a tight connection with ALS. Potential topics include, but are not limited to:

• Prognosis and diagnosis in sporadic and familial ALS
• Epigenetic regulatory and pathophysiological mechanisms in ALS
• Proteomic, bioinformatic and genome-wide association studies in ALS
• Biomarker discovery in ALS and other neurodegenerative diseases. An approach to less explored tissues and cells. Non-neuronal cells in ALS
• Therapeutic strategies based on potential biomarkers of ALS and its closed-linked neurodegenerative diseases
• Novel perspectives in other neurodegenerative diseases, such as proteinopathies, muscular dystrophy, Alzheimer’s or Parkinson’s diseases, and frontotemporal lobar degeneration (FTLD)

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/biochemistry/dals/ according to the following timetable: