BioMed Research International

Genetic and Epigenetic Effects of Environmental Mutagens and Carcinogens


Publishing date
08 May 2015
Status
Published
Submission deadline
19 Dec 2014

1University of Genoa, Genoa, Italy

2Third Military Medical University, Chongqing, China

3University of Sao Paulo, Sao Paulo, Brazil

4Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Rome, Italy


Genetic and Epigenetic Effects of Environmental Mutagens and Carcinogens

Description

Epigenetic mechanisms are flexible genomic modifications that can change genome function under exogenous influence and also provide a mechanism that allows for the stable propagation of gene-activity states from one generation of cells to the next. Several epigenetic mechanisms, with particular reference to microRNA alterations, DNA methylation, and histone modifications, can change genome function under exogenous influence. Recent investigations have examined the relationship between exposure to environmental carcinogens and epigenetics and have identified toxicants that modify epigenetic states. MicroRNAs are posttranscriptional regulators of gene expression involved in carcinogenesis, metastasis, and invasion. Thus, microRNAs are potentially useful as diagnostic and prognostic biomarkers as well as anticancer therapeutic targets. Many microRNAs undergo altered expression as consequence of exposure to carcinogens and these changes may be useful in carcinogenesis prevention. MicroRNAs have been also implicated in transgenerational epigenetic inheritance via the gametes. Other epigenetic mechanisms, like DNA methylation, are susceptible to environmental influence in both somatic and germ cells.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the genetics and epigenetic mechanisms of environmental mutagens and carcinogens.

We are particularly interested in articles describing the interactions derived from their own metabolism and microbiota as well as external factors such as diet, pharmaceuticals, and environmental compounds in relation to epigenetics mechanisms.

Potential topics include, but are not limited to:

  • Electromagnetic radiation from mobile and basic station as physical mutagens, further to chemical mutagens and epigenetic changes
  • Synergistic interactions between environmental exposure and ageing or genetic predisposition and epigenetic effects in the cancer risk
  • Environmental exposures to potentially aneugenic agents including therapeutic exposures and exposures associated with lifestyle habits and epigenetic modulation
  • Mechanisms and risk of chemically induced genetic and epigenetic changes in mammalian germ cells

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 608054
  • - Editorial

Genetic and Epigenetic Effects of Environmental Mutagens and Carcinogens

Alessandra Pulliero | Jia Cao | ... | Francesca Pacchierotti
  • Special Issue
  • - Volume 2015
  • - Article ID 698795
  • - Review Article

Bisphenol A Effects on Mammalian Oogenesis and Epigenetic Integrity of Oocytes: A Case Study Exploring Risks of Endocrine Disrupting Chemicals

Ursula Eichenlaub-Ritter | Francesca Pacchierotti
  • Special Issue
  • - Volume 2015
  • - Article ID 761703
  • - Review Article

Effect of Environmental Chemical Stress on Nuclear Noncoding RNA Involved in Epigenetic Control

Patrizio Arrigo | Alessandra Pulliero
  • Special Issue
  • - Volume 2015
  • - Article ID 949514
  • - Research Article

Impact of Cadmium on Intracellular Zinc Levels in HepG2 Cells: Quantitative Evaluations and Molecular Effects

Chiara Urani | Pasquale Melchioretto | ... | Laura Gribaldo
  • Special Issue
  • - Volume 2015
  • - Article ID 123484
  • - Review Article

Environmental Impact on DNA Methylation in the Germline: State of the Art and Gaps of Knowledge

Francesca Pacchierotti | Marcello Spanò
  • Special Issue
  • - Volume 2015
  • - Article ID 257090
  • - Research Article

Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts

Courtney E. Cross | Mai F. Tolba | ... | Sherif Z. Abdel-Rahman
  • Special Issue
  • - Volume 2015
  • - Article ID 194031
  • - Review Article

Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review

Olivia Torres-Bugarín | Nicole Macriz Romero | ... | María Guadalupe Zavala-Cerna
  • Special Issue
  • - Volume 2015
  • - Article ID 515798
  • - Review Article

Applying a Weight-of-Evidence Approach to Evaluate Relevance of Molecular Landscapes in the Exposure-Disease Paradigm

Sherilyn A. Gross | Kristen M. Fedak
  • Special Issue
  • - Volume 2015
  • - Article ID 293408
  • - Research Article

Heterogeneity of Genetic Damage in Cervical Nuclei and Lymphocytes in Women with Different Levels of Dysplasia and Cancer-Associated Risk Factors

Carlos Alvarez-Moya | Mónica Reynoso-Silva | ... | Alfredo I. Feria-Velasco
  • Special Issue
  • - Volume 2015
  • - Article ID 876047
  • - Research Article

Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells

Yoshikazu Arai | Koji Hayakawa | ... | Jun Ohgane
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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