BioMed Research International

Phytochemicals in Cancer Prevention and Therapy


Publishing date
18 Dec 2015
Status
Published
Submission deadline
31 Jul 2015

1University of Kentucky, Lexington, USA

2Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea

3DUKE-NUS Graduate Medical School, Singapore

4Johns Hopkins University, Maryland, USA

5Hamad Medical Corporation, Doha, Qatar


Phytochemicals in Cancer Prevention and Therapy

Description

Cancer is one of the leading causes of death worldwide and the incidence is on rise in both developing and developed countries. Drastic increase in the number of cancer cases reported each year can be due to early detection and accessibility to medical care especially in developed countries. But at the same time it can very well be attributed to the change in the life style and the exposure to many more environmental carcinogens than previously happened. The risk assessment studies also have shown a link between cancer and lifestyle.

Cancer is indeed a genetic disease where accumulations of mutations later initiate carcinogenesis. There is tremendous time, at least in case of some common cancers like colon, pancreas, and so forth from initiation to progression. We have the opportunity to inhibit the disease during this state where the patient’s health is not compromised by the disease. There is greater need for more effective and less toxic therapeutic and preventive strategies. Natural products have been used for the treatment of various diseases and are becoming an important research area for novel and bioactive molecules for drug discovery. Indeed, many chemotherapeutic drugs including paclitaxel and vinca alkaloids are developed from plant materials. Phytochemicals and dietary compounds have been used for the treatment of cancer throughout history due to their safety, low toxicity, and general availability. Scientifically it is proven that dietary phytochemicals can inhibit or slow down the progression of cancer in many animal models. These products have been extensively studied and have exhibited anticarcinogenic activities by interfering with the initiation, development, and progression of cancer through the modulation of various mechanisms including cellular proliferation, differentiation, apoptosis, angiogenesis, and metastasis.

Plants are provided with immense source of pharmacologically active components mainly secondary metabolites which are produced to combat the natural stress. Development of naturally derived anticancer drugs, therefore, is crucial, and isolation of novel compounds has become an important part of cancer research.

This special issue will accept original research articles and reviews that provide solid evidence to support the application of phytochemicals or dietary agents in prevention and treatment of cancer.

Potential topics include, but are not limited to:

  • Use of phytochemicals or dietary agents for mechanism based prevention of:
    • Environmental carcinogenesis
    • Inflammation
    • Tumor angiogenesis
    • Metastasis
    • Immune system
    • Apoptosis
    • Autophagy
    • Cancer cell metabolism
    • Cancer stem cells
    • Chemo/radio therapy
    • Radio sensitization
    • Adjuvant therapy

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 324021
  • - Editorial

Phytochemicals in Cancer Prevention and Therapy

Poyil Pratheeshkumar | Young-Ok Son | ... | Kodappully Sivaraman Siveen
  • Special Issue
  • - Volume 2015
  • - Article ID 414250
  • - Research Article

Black Rice Anthocyanins Suppress Metastasis of Breast Cancer Cells by Targeting RAS/RAF/MAPK Pathway

Xiang-Yan Chen | Jie Zhou | ... | Xiao-Ping Yu
  • Special Issue
  • - Volume 2015
  • - Article ID 497934
  • - Review Article

Coevolution between Cancer Activities and Food Structure of Human Being from Southwest China

Yawen Zeng | Juan Du | ... | Xiaomeng Yang
  • Special Issue
  • - Volume 2015
  • - Article ID 506327
  • - Review Article

Systematic Review of the Use of Phytochemicals for Management of Pain in Cancer Therapy

Andrew M. Harrison | Fabrice Heritier | ... | Mikhail A. Dziadzko
  • Special Issue
  • - Volume 2015
  • - Article ID 817624
  • - Research Article

Antiproliferative Activity of T. welwitschii Extract on Jurkat T Cells In Vitro

Batanai Moyo | Stanley Mukanganyama
  • Special Issue
  • - Volume 2015
  • - Article ID 630397
  • - Research Article

Curcumin Enhanced Busulfan-Induced Apoptosis through Downregulating the Expression of Survivin in Leukemia Stem-Like KG1a Cells

Guangyang Weng | Yingjian Zeng | ... | Kunyuan Guo
  • Special Issue
  • - Volume 2015
  • - Article ID 847457
  • - Research Article

Antiproliferative and Antiestrogenic Activities of Bonediol an Alkyl Catechol from Bonellia macrocarpa

Rosa Moo-Puc | Edgar Caamal-Fuentes | ... | Dennis B. Lubahn
  • Special Issue
  • - Volume 2015
  • - Article ID 856349
  • - Research Article

Effect and Mechanism of Total Flavonoids Extracted from Cotinus coggygria against Glioblastoma Cancer In Vitro and In Vivo

Gang Wang | JunJie Wang | ... | Fei Li
  • Special Issue
  • - Volume 2015
  • - Article ID 916902
  • - Research Article

Garcinia dulcis Fruit Extract Induced Cytotoxicity and Apoptosis in HepG2 Liver Cancer Cell Line

Mohd Fadzelly Abu Bakar | Nor Ezani Ahmad | ... | Azizul Isha
  • Special Issue
  • - Volume 2015
  • - Article ID 415269
  • - Research Article

The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of Cisplatin and Doxorubicin on Human Hepatocellular Carcinoma Cells

Liang-Tzung Lin | Chen-Jei Tai | ... | Cheng-Jeng Tai
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision77 days
Acceptance to publication52 days
CiteScore2.410
Impact Factor2.197
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