BioMed Research International

Successful Cognitive Aging: Between Functional Decline and Failure of Compensatory Mechanisms


Status
Published

Lead Editor

1University Pierre and Marie Curie, Paris, France

2Lille 2 University, Lille, France

3Université Saint-Quentin-en-Yvelines, Lille, France

4Université François Rabelais, Tours, France

5INRS-Institut Armand-Frappier, Laval, Canada


Successful Cognitive Aging: Between Functional Decline and Failure of Compensatory Mechanisms

Description

Normal brain aging is considered “successful” when it is associated with low functional decline at different levels of complexity. These include molecular, cellular, and neuronal network, as well as more integrated levels such as metabolic, sensory, motor, and behavioral levels. However, a new hypothesis has recently pointed to the importance of compensatory mechanisms for “successful” brain aging. These compensatory mechanisms are aimed to “correct” age-related dysfunctions in a homeostatic manner. According to this new hypothesis, neurodegeneration results predominantly from the gradual, age-related loss of compensatory mechanisms that correct for age-accumulated dysfunctions. This concept may appear fundamentally at odds with previous hypotheses postulating that neurodegeneration results mainly from an accumulation of dysfunctions at all levels of complexity.

This special issue aims to gather evidence that these two hypotheses are closely related. Neurodegenerative diseases become overt likely when the level of age-associated dysfunctions over-passes the capacity of the homeostatic compensatory mechanisms. Guiding future research with such a conceptual frame should bring useful clues to understanding the enormous potential of the mammalian brain and how to exploit it to achieve successful cognitive aging.

Potential topics include, but are not limited to:

  • Age-related dysfunctions at the molecular (mitochondrial energy production, DNA repair mechanisms, and Ca2+ buffering capacity…) and cellular (neuronal dendritic branching and spine remodeling, glutamate uptake capacity of astrocytes, and threshold of microglia activation…) levels
  • Identification of putative compensatory mechanisms such as more efficient detoxification of reactive oxygen radicals, steroidogenesis, and DNA repair mechanisms etc…
  • Understanding age-dependent control of neuronal excitability and reorganization of neuronal microcircuits and networks
  • Differences in the activation of brain regions during cognitive tasks between young and old neurologically normal subjects
  • Synergistic contribution of physical activity and cognitive stimulation to foster neuroplasticity during aging
  • Role of age-related alterations in homeostatic reflex set-points in the human brain with a focus on nutritional drive in the elderly
  • Brain vascular disorders: causes, consequences, or associated lesions inage-related neurodegenerative diseases

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 367407
  • - Editorial

Successful Cognitive Aging: Between Functional Decline and Failure of Compensatory Mechanisms

Marc Verny | Emmanuel Moyse | Slavica Krantic
  • Special Issue
  • - Volume 2015
  • - Article ID 640657
  • - Research Article

Healthy Aging and Compensation of Sentence Comprehension Auditory Deficits

Marcela Lima Silagi | Camila Maia Rabelo | ... | Letícia Lessa Mansur
  • Special Issue
  • - Volume 2015
  • - Article ID 438908
  • - Review Article

Cognitive Interventions in Older Persons: Do They Change the Functioning of the Brain?

Yindee van Os | Marjolein E. de Vugt | Martin van Boxtel
  • Special Issue
  • - Volume 2015
  • - Article ID 590216
  • - Research Article

Neural Processing of Emotional Prosody across the Adult Lifespan

Liliana Ramona Demenescu | Yutaka Kato | Klaus Mathiak
  • Special Issue
  • - Volume 2015
  • - Article ID 153437
  • - Clinical Study

The Association between Cerebral White Matter Lesions and Plasma Omega-3 to Omega-6 Polyunsaturated Fatty Acids Ratio to Cognitive Impairment Development

Michihiro Suwa | Shigeru Yamaguchi | ... | Masaya Kino
  • Special Issue
  • - Volume 2015
  • - Article ID 748212
  • - Review Article

Working Memory and Executive Function Decline across Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

Anna-Mariya Kirova | Rebecca B. Bays | Sarita Lagalwar
  • Special Issue
  • - Volume 2015
  • - Article ID 415458
  • - Research Article

Trying to Put the Puzzle Together: Age and Performance Level Modulate the Neural Response to Increasing Task Load within Left Rostral Prefrontal Cortex

Eva Bauer | Gebhard Sammer | Max Toepper
BioMed Research International
 Journal metrics
Acceptance rate30%
Submission to final decision70 days
Acceptance to publication36 days
CiteScore2.410
Impact Factor2.197
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