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Behavioural Neurology
Volume 2018, Article ID 9421098, 10 pages
https://doi.org/10.1155/2018/9421098
Review Article

REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB)

1Department of Neurology, Show Chwan Memorial Hospital, Changhua, Taiwan
2Department of Neurology, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan
3Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
4Sleep Center, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan
5Vertigo and Balance Impairment Center, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan

Correspondence should be addressed to Dean Wu; moc.liamg@93120uygnit

Received 1 February 2018; Revised 30 March 2018; Accepted 8 April 2018; Published 19 June 2018

Academic Editor: Ying-Jui Ho

Copyright © 2018 Po-Chi Chan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rapid eye movement sleep behavior disorder (RBD) is a parasomnia, with abnormal dream-enacting behavior during the rapid eye movement (REM) sleep. RBD is either idiopathic or secondary to other neurologic disorders and medications. Dementia with Lewy bodies (DLB) is the third most common cause of dementia, and the typical clinical presentation is rapidly progressive cognitive impairment. RBD is one of the core features of DLB and may occur either in advance or simultaneously with the onset of DLB. The association between RBD with DLB is widely studied. Evidences suggest that both DLB and RBD are possibly caused by the shared underlying synucleinopathy. This review article discusses history, clinical manifestations, possible pathophysiologies, and treatment of DLB and RBD and provides the latest updates.