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Biochemistry Research International
Volume 2012, Article ID 715197, 9 pages
http://dx.doi.org/10.1155/2012/715197
Review Article

Application of Echocardiography on Transgenic Mice with Cardiomyopathies

1Department of Cardiology, The Children’s Hospital of Chongqing Medical University, Chongqing 400014, China
2Department of Biomedical Science, College of Medicine, Florida Atlantic University, Boca Raton, FL 33431, USA
3Department of Physiology, Wayne State University College of Medicine, Detroit, MI 48201, USA

Received 9 January 2012; Accepted 12 March 2012

Academic Editor: Sachio Morimoto

Copyright © 2012 G. Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cardiomyopathies are common cardiac disorders that primarily affect cardiac muscle resulting in cardiac dysfunction and heart failure. Transgenic mouse disease models have been developed to investigate the cellular mechanisms underlying heart failure and sudden cardiac death observed in cardiomyopathy cases and to explore the therapeutic outcomes in experimental animals in vivo. Echocardiography is an essential diagnostic tool for accurate and noninvasive assessment of cardiac structure and function in experimental animals. Our laboratory has been among the first to apply high-frequency research echocardiography on transgenic mice with cardiomyopathies. In this work, we have summarized our and other studies on assessment of systolic and diastolic dysfunction using conventional echocardiography, pulsed Doppler, and tissue Doppler imaging in transgenic mice with various cardiomyopathies. Estimation of embryonic mouse hearts has been performed as well using this high-resolution echocardiography. Some technical considerations in mouse echocardiography have also been discussed.