Synthesis of Surfactants Derived from 2-Mercaptobenzimidazole and Study of Their Acute Toxicity and Analgesic and Psychotropic Activities

Table 3

Results of the sedative activity of 2-mercaptobenzimidazole at the doses of 200 and 400 mg/kg.

		Witness	Bromazepam	2-Mercaptobenzimidazole (200 mg/kg)	2-Mercaptobenzimidazole (400/kg)
Traction test	Percentage of falls (%)	0	100	33.33	100
	Average fall time (s)	0	10.0 ± 0.9	52.71 ± 30.42	10.38 ± 0.14
	Average recovery time (s)	0.5 ± 0.1	0	33.08 ± 3.74	0
Chemney test	Average time to climb the chemney (s)	3.40 ± 0.5	>120	>120	>120
Hole-board test	Number of holes explored over 5 min	7 ± 1	0	2.52 ± 1.03	1.68 ± 0.99
Rotarod test	Time spent on stem (s)	120 ± 0	1.2 ± 0.9	10.80 ± 1.84	1.60 ± 0.43

; .