Impact of Highly Saturated versus Unsaturated Fat Intake on Carbohydrate Metabolism and Vascular Reactivity in Rat

Figure 6

Effects of diets on relaxation of phenylephrine-precontracted aortic rings. Endothelium-dependent relaxation induced by acetylcholine (a) and endothelium-independent relaxation induced by SNP (b) and relaxant effect of insulin (c). Graphs represent cumulative response curves to acetylcholine (0.01–10 µM) in the absence and in the presence of L-NAME (10 µM), SNP (0.1 nM–1 µM) and Insulin (0.1–50 µM) on aortic rings previously contracted with 10 µM Phe. Histograms represent the maximal relaxation obtained for Ach and SNP and the relaxation induced by 20 µM insulin. Results were expressed as mean values ± SD, n = 7-8 animals per group. The limit of statistical significance was set at . The group mean values with different letters (a, b, c) are significantly different. Ach: acetylcholine; L-NAME: nitro-L-arginine methyl ester; SNP: sodium nitroprusside.

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(b)

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