Thyroid Function and Cognition during Aging

Table 2

Relation between thyroid function and cognition in euthyroid elderly (>65 years old) (A: attention; BD: block design of WAIS-R; CST: concept shifting test; DRS: dementia rating scale; DS: digit span forward and backward of WAIS-R; FR: figure rotation; FT3: free T3; G: global; LDC: letter digit coding test; LW: list of words; M: memory; MMSE: Mini-Mental State Examination; MRT: median reaction time tests; NS: not specified; NTI: nonthyroidal illnesses; O: orientation; PS: psychomotor speed; RBP: Rivermead behavioral profile; ST: Stroop test; TMTA&B: trail making test A and B; TSH: thyroid stimulating hormone; TT4: total T4; VF: verbal fluency; VSA: visuospatial ability; WAIS-R: Wechsler adult intelligence scale-revised; WLT: word learning task).

Source	Age, years		Gender			Population health status	Altered cognitive domain	Thyroid function indicator	Measures
	mean	range	women	men	N
van Boxtel et al. [14]	60	49–71	NS	NS	120	Healthy + hypo	M	TSH	WLT, CST, ST
Prinz et al. [15]	72	65–78	0	44	44	Healthy	G, VF	TT4	WAIS-R, DRS, VF, FR, RBP, MMSE, MRT
Volpato et al. [16]	72	75–80	464	0	464	Heathy + NTI	O, M	TT4	MMSE
Wahlin et al. [17]	84	75–96	159	41	200	Healthy	M	TSH	DS-WAIS-R, LW, TMTA&B, BD
Wahlin et al. [18]	NS	75–93	39	6	45	Healthy	VF, VSA→ M	TSH	RT, BD, VF, TMTA&B
Gussekloo et al. [19]		85–89	369	189	558	Mixed	G, A, M, PS	FT3	MMSE, ST, LDC, WLT