Thyroid Function and Cognition during Aging

Table 3

Cognitive impairment in subclinical hypothyroidism (A: attention; BMT: Bingley's memory test; BVRT: Benton's visual retention test; CS: Corsi's span forward and backward; DC: drawing copy; DSB: digit span backward; DSCT: digit symbol coding test from the WAIS-III; DSF: digit span forward; DSS: digit symbol substitution; EF: executive functions; IFT: identical forms test of Thurstone; IST: Isaacs' set test of verbal fluency; LM: logical memory test; M: memory; MMSE: Mini-Mental State Examination; NBT: N back test; PS: perceptual speed; RAVLT: Rey auditory verbal learning test; RF: Rey's figure; RPM: Raven's progressive matrices; RT: reaction time; RW: Rey's words immediate and delayed recall; S: speed test; ScT: Scribble test; TMTAB: trail making test A and B; VF: verbal fluency; VF: verbal fluency test; WAIS: Wechsler adult intelligence scale; WFT: word fluency test; WLT: word learning test; WMS: Wechsler memory scale; ZBT: Zazzo's barring test).

Source	Participants				Impaired cognitive domain	Tests	Treatment outcome
	Age, years	Gender
	Mean ± SD and/or (Range)	women	men	N
del Ser Quijano	38 ± 9.5	12	3	15	A, M, VF, EF	MMSE, WAIS, RT, BVRT, RF, WLT, VF, TMTAB	Improvement after 6 months
et al. [26]	(23–53)
Monzani	39 ± 9	13	1	14	M	WMS	Improvement after 6 months
et al. [24]	(29–47)
Baldini	55 ± 9	19	0	19	M	WMS, ScT, S	Improvement after 3 months
et al. [25]	(28–68)
Bono et al. [29]	52 ± 13.5	36	0	36	A, VF	MMSE, DSF, DSB, CS, RW, TMTAB, RPM, DC, VF	Improvement after 6 months
	(31–70)
Nyström et al. [30]	(51–73)	17	0	17	PS, M, S	IFT, BMT, RT	Improvement after 6 months
Jaeschke et al. [31]	68 ± 9.4	28	8	36	M, PS	LM, WLT, WFT, DSS, TMT	Improvement after 10 months
Jensovsky et al. [23]	62 ± 6.8	20	0	20	M	WMS	Improvement after 6 months
Manciet et al. [28]	(65–85)	256	169	425	VF	MMSE, BVRT, WAIS, ZBT, IST	No treatment
Cook et al. [27]	74 ± 3.9	NS	NS	15	M,VF	MMSE, RAVLT, DSCT, NBT, DSB	No treatment