Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice

Table 2

Age-related dynamics of biochemical parameters in the serum of PARP-1^−/− and PARP-1^+/+ mice.

Parameters	PARP-1^+/+		PARP-1^−/−
	4 months, 𝑛=10	20 months, 𝑛=10	4 months, 𝑛=10	20 months, 𝑛=10
Total protein, g/l	45.19±1.15	48.33±1.10	41.88±1.47^a	25.22±0.46^c, ##
Albumin, g/l	21.69±0.52	22.04±0.42	19.18±1.13^*	20.99±0.29^#
Glucose, mM/l	7.27±0.30	6.89±1.33	7.51±0.60	8.31±1.57
Cholesterol, mM/l	3.09±0.09	2.86±0.08	2.86±0.17	2.83±0.15
Triglycerides, mM/l	0.89±0.04	0.88±0.08	0.75±0.07	1.00±0.29
Urea, mM/l	10.46±0.43	9.33±0.27	8.79±0.94	10.31±0.41
Creatinine,μM/l	31.70±1.34	32.17±3.81	27.83±1.68	31.45±6.0
Uric acid, μM/l	43.60±5.46	133.92±8.94^c	54.10±21.55	66.27±8.10^###
Calcium, mM/l	1.87±0.05	2.09±0.03^b	1.43±0.16^**	1.98±0.04^b#
Alanine-amino-transferase. U/l	56.50±4.85	43.42±2.48^a	50.82±4.48	44.73±5.62
Aspartate-amino-transferase, U/l	341.80±40.62	231.25±21.86^a	259.33±25.93	209.36±16.38
Alkaline phosphatase, U/l	122.80±10.21	129.83±17.17	125.67±8.03	92.00±10.76^a
Lactate dehydrogenase, U/l	1330±140.93	897.42±83.54^b	917.91±131.33^*	780.64±44.0
γ- Glutamyl-transferase, U/l	6.38±1.92	4.55±0.29	4.9±0.40	5.38±0.6
α-Amylase, U/l	1518.33±59.93	2519.17±336.99^b	542.00±186.38^***	2802.0±562.86^b

Significant in comparison with the control of the same strain at the age of 4 months: a:𝑃<.05; b: 𝑃<.01; c: 𝑃<.001;
Significant in comparison with the PARP-1^+/+ at the age of 4 months: ^*: 𝑃<.05.^**:𝑃<.01; ^***: 𝑃<.002.
Significant in comparison with the PARP-1^+/+ at the age of 20 months: ^#: 𝑃<.05; ^##: 𝑃<.01; ^###: 𝑃<.001.