Review Article

Cobalamin Deficiency in Elderly Patients: A Personal View

Table 1

Definitions of cobalamin (vitamin B12) deficiency [57].

(i) Serum cobalamin levels <150 pmol/L and clinical features and/or hematological anomalies related to cobalamin deficiency
(ii) Serum cobalamin levels <150 pmol/L (<200 pg/mL) on 2 separate occasions
(iii) Serum cobalamin levels <150 pmol/L and total serum homocysteine levels >13 μmol/L or methylmalonic acid levels >0.4 μmol/L (in the absence of renal failure and folate and vitamin B6 deficiencies)
(iv) Low serum holotranscobalamin levels <35 pmol/L