|
| Hematological
manifestations | Neuro-psychiatric
manifestations
| Digestive manifestations | Other manifestations |
|
| – Frequent: macrocytosis, hypersegmentation of the neutrophils, aregenerative macrocytary anemia, LDH and bilirubin elevation, medullary megaloblastosis (“blue spinal cord”) | – Frequent:
polyneurites (especially sensitive ones), ataxia, Babinski’s phenomenon | – Classic:
Hunter’s glossitis, jaundice, LDH and bilirubin elevation (“intramedullary
destruction”) | – Under
study: atrophy of the vaginal mucosa and chronic vaginal and urinary
infections (especially mycosis), hypofertility and repeated miscarriages
(connection with cobalamin deficiency under study), venous thromboembolic
disease, angina (hyperhomocysteinemia), osteoporosis |
| – Rare:
isolated thrombocytopenia and neutropenia, pancytopenia | – Classic:
combined sclerosis of the spinal cord | – Debatable:
abdominal pain, dyspepsia, nausea, vomiting, diarrhea, disturbances in
intestinal functioning |
| – Very rare: hemolytic anemia,
thrombotic microangiopathy (presence of schistocytes) | – Rare: cerebellar syndromes affecting the cranial nerves including optic neuritis,
optic atrophy, urinary, and/or
fecal incontinence | – Rare:
resistant and recurring mucocutaneous ulcers cobalamin
deficiency |
| – Under study: changes in the
higher functions, even dementia, stroke and atherosclerosis
(hyperhomocysteinemia), parkinsonian syndromes, depression, multiple
sclerosis |
|
