Ten-Year Survival in 75-Year-Old Men and Women: Predictive Ability of Total Cholesterol, HDL-C, and LDL-C
Table 2
Hazard ratios for major cardiovascular event defined as hospitalization or death caused by myocardial infarction, stroke, or ruptured aortic aneurysm or all-cause mortality according to serum levels of cholesterol and its subfractions.
Major cardiovascular event
All-cause mortality
Men ()
Women ()
Men ()
Women ()
HR (95% CI)*
P
HR (95% CI)*
P
HR (95% CI)*
P
HR (95% CI)*
P
Total cholesterol
1.01 (0.96–1.07)
.68
1.00 (0.93–1.07)
.94
0.97 (0.92–1.02)
.29
0.95 (0.90–1.00)
.065
LDL-C
1.02 (0.96–1.09)
.44
1.02 (0.93–1.11)
.72
0.97 (0.92–1.03)
.34
0.99 (0.92–1.06)
.73
Non-HDL-C
1.03 (0.98–1.09)
.25
1.01 (0.95–1.08)
.77
0.99 (0.95–1.04)
.82
0.97 (0.93–1.02)
.20
Total cholesterol/HDL-C ratio
1.19 (1.00–1.40)
.046
1.13 (0.89–1.45)
.32
1.10 (0.95–1.29)
.20
1.07 (0.90–1.29)
.44
HDL-C
0.76 (0.61–0.94)
.011
0.93 (0.78–1.10)
.40
0.78 (0.65–0.94)
.009
0.93 (0.82–1.07)
.32
HDL-C adjusted†
0.71 (0.55–0.90)
.006
1.01 (0.83–1.23)
.94
0.76 (0.62–0.94)
.011
0.93 (0.80–1.07)
.31
*Hazard ratios and 95% confidence intervals for every unit increase of the total cholesterol/HDL-C ratio and for every 10 mg/dL increase of the other independent variables. †Adjusted for smoking, non-HDL-C, triglycerides, diabetes, hypertension, previous stroke, and previous myocardial infarction.
