Simulations of Myenteric Neuron Dynamics in Response to Mechanical Stretch

Figure 1

Optimizations of the model to experimentally recorded membrane potentials. (a) Comparison between the experimental recordings (dashed line) of the porcine sAHP neuron, under 100 pA, with 70 ms injection of rectangular electrical current pulses and the model response (solid lines) to the same input. The optimized conductances are listed in Table 1: sAHP neuron. (b) Comparison between the experimental recording (dashed line) of the porcine mAHP neuron, to 60 pA, with 140 ms injection of rectangular electrical current pulses and the model response (solid lines) to the same input. The optimized conductances are listed in Table 1: mAHP neuron. (c) Comparison between the experimental recording (dashed line) from a neuron in a tissue strip under 20% longitudinal stretch and with 200PA, 500 ms injection of the current pulse and the model response (solid lines) to the same input. The optimized conductances are listed in Table 1: neuron under stretch. The experimental recordings of the sAHP and mAHP were reproduced from Figure 1(b) (sAHP) and Figure 3C (mAHP) in the study by Cornelissen et al. [21], and the recordings on the mechanical stretch neuron were from Figure 5Ba in the study by Kunze et al. [2].

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