Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target

Figure 2

Hepatic MT gene regulation in inflammation. GREs: glucocorticoid responsive elements, GRF: cytoplasmic glucocorticoid receptor complex, MREs: metal response elements, MTF-1: metal transcription factor-1, STATs: signal transducers and activator proteins, and ROS: reactive oxygen species. Adapted from Coyle, et al. [37].