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Canadian Journal of Infectious Diseases and Medical Microbiology
Volume 2018 (2018), Article ID 1857170, 12 pages
https://doi.org/10.1155/2018/1857170
Research Article

De Novo Sequencing of a Sparassis latifolia Genome and Its Associated Comparative Analyses

The Institute of Edible Fungi, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350003, China

Correspondence should be addressed to Yan-quan Lin; moc.361@604-qyl

Received 31 July 2017; Revised 30 October 2017; Accepted 2 November 2017; Published 25 February 2018

Academic Editor: Jialiang Yang

Copyright © 2018 Donglai Xiao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Known to be rich in β-glucan, Sparassis latifolia (S. latifolia) is a valuable edible fungus cultivated in East Asia. A few studies have suggested that S. latifolia is effective on antidiabetic, antihypertension, antitumor, and antiallergen medications. However, it is still unclear genetically why the fungus has these medical effects, which has become a key bottleneck for its further applications. To provide a better understanding of this fungus, we sequenced its whole genome, which has a total size of 48.13 megabases (Mb) and contains 12,471 predicted gene models. We then performed comparative and phylogenetic analyses, which indicate that S. latifolia is closely related to a few species in the antrodia clade including Fomitopsis pinicola, Wolfiporia cocos, Postia placenta, and Antrodia sinuosa. Finally, we annotated the predicted genes. Interestingly, the S. latifolia genome encodes most enzymes involved in carbohydrate and glycoconjugate metabolism and is also enriched in genes encoding enzymes critical to secondary metabolite biosynthesis and involved in indole, terpene, and type I polyketide pathways. As a conclusion, the genome content of S. latifolia sheds light on its genetic basis of the reported medicinal properties and could also be used as a reference genome for comparative studies on fungi.