Canadian Journal of Infectious Diseases and Medical Microbiology

Computational Tools for Investigating Pathogen, Pathogen-Host Interaction, and Infectious Disease


Status
Published

Lead Editor

1Icahn School of Medicine at Mount Sinai, New York, USA

2Hunan University, Hunan, China

3Yangzhou University, Yangzhou, China

4University of East Anglia, Norwich, UK


Computational Tools for Investigating Pathogen, Pathogen-Host Interaction, and Infectious Disease

Description

Recent developments of high-throughput sequencing technologies and systems biology methods open novel opportunities to investigate pathogen, pathogen-host interactions, and infectious diseases at system-wide scales. For example, the tool antigenic map has been adopted by Centers for Disease Control and Prevention in US to help select vaccine strains for seasonal influenza each year. Disease transmission models have been used to study and help inform public health interventions for a few infectious diseases for human and animals. However, the clinical application of computational tools is still on its early stage.

With more and more data available for pathogens and their hosts at genome, transcriptome, proteome, mythylome, and epigenome levels, computational modelling, big data analysis, and systems biology have become more and more important in revealing the biological mechanisms underlying these data, unraveling the secrets behind pathogen evolution, infection, and pathogen-host interactions. Possible immediate applications include the following: (1) the whole genome sequence data analysis of pathogen allows investigation of the genomic determinants of disease severity; (2) the study of the interaction between host and pathogen would allow a better understanding of the diseases and thus a better treatment. For example, through the whole genome sequencing study on the integration of HBV or HCV virus DNA into human genome, one would be able to understand probably over half cases of liver cancers; (3) the sequencing data of patients (and their microenvironment) with drug resistance will help identify the resistance genes and thus contribute to improving the drug efficacy for infectious diseases. These studies are critical towards a better surveillance on infectious diseases and a better therapy against pathogens.

We solicit high quality original research as well as review articles for investigating pathogen, pathogen-host interaction, and infectious disease.

Potential topics include but are not limited to the following:

  • Next generation sequencing techniques in infectious diseases and medical microbiology
  • Big data analysis in virology, infectious diseases, and medical microbiology
  • Systems biology analysis in host-pathogen interaction
  • Metagenomic approach in virology and microbiology
  • Computer-assisted studies of function and structure of viruses
  • Identification of genomic variants of pathogens or hosts associated with disease
  • Identification of pathogen-induced alterations in host gene expression and epigenetics
  • Evolution of pathogen and coevolution of pathogen and host
  • Computational methods in predicting antigenic sites and drug sensitivity of specific pathogens
  • Predicative model of disease state
  • Infectious disease transmission models

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 5476875
  • - Editorial

Computational Tools for Investigating Pathogen, Pathogen-Host Interaction, and Infectious Disease

Jialiang Yang | Bo Liao | ... | Taoyang Wu
  • Special Issue
  • - Volume 2018
  • - Article ID 9139306
  • - Research Article

Development of Microsatellite Markers for the Nipa Palm Hispid Beetle, Octodonta nipae (Maulik)

Zhiming Chen | Jun Chen | ... | Guihua Wang
  • Special Issue
  • - Volume 2018
  • - Article ID 3217473
  • - Research Article

Structure Analysis of Effective Chemical Compounds against Dengue Viruses Isolated from Isatis tinctoria

Bo Gao | Jianming Zhang | Lianhui Xie
  • Special Issue
  • - Volume 2018
  • - Article ID 3420535
  • - Research Article

The Role of Migration in Maintaining the Transmission of Avian Influenza in Waterfowl: A Multisite Multispecies Transmission Model along East Asian-Australian Flyway

Akira Endo | Hiroshi Nishiura
  • Special Issue
  • - Volume 2018
  • - Article ID 1875217
  • - Review Article

Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies

Gerald Mboowa | Ivan Sserwadda | ... | Norah Namatovu
  • Special Issue
  • - Volume 2018
  • - Article ID 8402839
  • - Research Article

Identification of Functional Domain(s) of Fibrillarin Interacted with p2 of Rice stripe virus

Luping Zheng | Jie He | ... | Ruoxue Meng
  • Special Issue
  • - Volume 2018
  • - Article ID 1857170
  • - Research Article

De Novo Sequencing of a Sparassis latifolia Genome and Its Associated Comparative Analyses

Donglai Xiao | Lu Ma | ... | Yan-quan Lin
  • Special Issue
  • - Volume 2017
  • - Article ID 9073172
  • - Research Article

Pathogenicity and Whole Genome Sequence Analysis of a Pseudorabies Virus Strain FJ-2012 Isolated from Fujian, Southern China

Xue-min Wu | Qiu-yong Chen | ... | Lun-jiang Zhou
Canadian Journal of Infectious Diseases and Medical Microbiology
 Journal metrics
Acceptance rate28%
Submission to final decision44 days
Acceptance to publication25 days
CiteScore2.400
Impact Factor1.520
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.