In Vivo 6-([¹⁸F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity

Figure 5

IHC for AH2A, AH2B, AH3, and AH4 in the hippocampus. Image presentation is the same as in Figure 4. Original magnification, upper: ×40 in the hippocampus, lower: ×100 in the Ca3. AH3 staining was suppressed in a dose-dependent manner in the CA3 and dentate gyrus of mice in Groups A (Cis 2 mg/kg) and B (Cis 4 mg/kg) and was almost equal in Group C (Cis 4 mg/kg+ SAHA 300 mg/kg), compared with a control mouse. Scale bar, 100 μm.