Voxel Scale Complex Networks of Functional Connectivity in the Rat Brain: Neurochemical State Dependence of Global and Local Topological Properties

Table 3

Differences in clustering coefficient c by VOI compared to vehicle network.

Brain region	VOI	Amphetamine	Fluoxetine	Nicotine
Prefrontal cortex	Cg	ns	+++	ns
	mPFC	ns	+++	++
Somatosensory and motor cortex	M1	+++	+++	+++
	S1BF	+++	+++	+++
	S1FL	+++	+++	+++
Other cortex	ctxV	−−−	+++	+++
	Ins	++	ns	+++
	PtA	−−−	+++	+++
Hippocampus	hcAD	−−−	−	ns
	hcS	−−−	+++	++
	hcV	−−−	+++	ns
Striatum	CPu	−−−	+++	+++
Thalamus	thalDL	−−−	+++	+++
	thalMD	−−−	+++	ns
	thalVM	−−−	+++	ns

“+” signs indicate significantly greater k compared to vehicle while “−” signs reflect significantly lower k, determined in each case using Bonferroni-corrected Mann-Whitney tests: + or – indicates 𝑃_𝑐<0.05, ++ or −− indicates 𝑃_𝑐<0.01, and +++ or −−− indicates 𝑃_𝑐<0.001. (See Table 2 for abbreviation definitions.)