Research Article
Likelihood-Ratio-Test Methods for Drug Safety Signal Detection from Multiple Clinical Datasets
Table 3
Results of PPIs data (for PLandPPI vs. PL). obsstat is the statistics shown in Table
1 for different methods, obtained from the observed data.
| | 1st occurrence of AEOST | Repeated occurrences of AEOST | | obsstat | value | 95% threshold | obsstat | value | 95% threshold |
| Individual study analysis using regular LRT | s = 1 | 0.12 | 0.99 | 1.79 | 0.93 | 0.438 | 1.96 | s = 2 | 4.16 | 0.004 | 2.10 | 24.28 | 0 | 2.00 | s = 3 | 0.56 | 0.61 | 1.73 | 1.18 | 0.243 | 1.18 | s = 4 | 1.83 | 0.07 | 2.04 | 4.63 | 0.006 | 2.03 | s = 5 | 1.54 | 0.137 | 1.69 | 4.88 | 0.006 | 2.27 | s = 6 | 2.43 | 0.031 | 0.97 | 3.97 | 0.009 | 1.17 | Simple pooled analysis using regular LRT | | 6.12 | 0.003 | 1.78 | 34.27 | 0.0 | 1.83 | MMLR | | 4.16 | 0.006 (from s = 2) | 2.43 | 24.28 | 0 (from s = 2) | 2.47 | wLRn | | 2.81 | 0.019 | 1.92 | 14.02 | 0 | 2.12 |
|
|