Rare Histological Variants of Liver Cancer and Their Management: A Single-Institution Experience

Table 1

Summary of selected prior case reports of liver cancer with rare histological features.

Reference	Patient demographics	Histological variant	HBV/HCV status	Tumor size (cm)	Solitary or multiple	Treatment	Vital status
Sakhuja et al. [13]	32, F	Clear cell	−/−	18	Solitary	Hepatic resection	Alive
Albores-Saavedra et al. [14]	63, M	Clear cell	−/−	0.9	Solitary	Hepatic resection	Alive
Albores-Saavedra et al. [14]	25, F	Clear cell	−/−	1.1	Solitary	Hepatic resection	Alive
Albores-Saavedra et al. [14]	64, M	Clear cell	−/−	6	Solitary	Hepatic resection	Alive
Pecorella et al. [17]	35, F	Clear cell	−/−	NR	NR	Total hepatectomy, liver transplantation	Alive
Toriyama et al. [18]	56, M	Clear cell	+/−	2.2	Solitary	Surgical resection, adjuvant chemotherapy	Alive
Kothadia et al. [19]	51, F	Clear cell	−/−	20.7	Multiple	Transarterial chemoembolization	Alive
Chable-Montero et al. [15]	26, F	Follicular thyroid-like	−/−	NR	Solitary	Hepatic resection, adjuvant chemotherapy	Dead
Fornelli et al. [16]	52, M	Follicular thyroid-like	−/−	18	Solitary	None	Alive
Mittal et al. [20]	23, F	Follicular thyroid-like	−/−	12.1	Solitary	Hepatic resection	Alive
Chen et al. [21]	59, F	Follicular thyroid-like	+/−	3	Solitary	Hepatic resection	Alive
Hiraki et al. [22]	45, M	Undifferentiated	+/−	11.5	Solitary	Hepatic resection	Alive
Maeda et al. [23]	56, M	Undifferentiated	−/−	Very small	Multiple	None	Dead

HBV = hepatitis B virus; HCV = hepatitis C virus; M = male; F = female; NR = not reported. EBV = Epstein–Barr virus; cHCC/CCA = combined hepatocellular-cholangiocarcinoma.