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Case Reports in Immunology
Volume 2015, Article ID 286380, 4 pages
Case Report

Does the Maternal Serum IgG Level during Pregnancy in Primary Antibody Deficiency Influence the IgG Level in the Newborn?

1Epsom and St Helier University Hospitals NHS Trust, Carshalton, Surrey SM5 1AA, UK
2St Georges University of London, London SW17 0RE, UK
3St George’s University Hospitals NHS Foundation Trust, Tooting, London SW17 0QT, UK

Received 18 June 2015; Revised 17 August 2015; Accepted 18 August 2015

Academic Editor: Alessandro Plebani

Copyright © 2015 Vasantha Nagendran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To find out if the serum IgG level in the newborn baby was affected by low maternal serum IgG during pregnancy in two newly diagnosed primary antibody deficient patients. Method. Infant cord blood IgG level was compared with maternal IgG level in 2 mothers with newly diagnosed primary antibody deficiency, who declined replacement IgG treatment during pregnancy. Results. Both mothers delivered healthy babies with normal IgG levels at birth. Conclusions. The normal IgG levels and sound health in these 2 babies in spite of low maternal IgG throughout pregnancy raise interesting discussion points about maternofoetal immunoglobulin transport mechanisms in primary antibody deficiency.