An Unexpected Complete Remission of Advanced Intestinal-Type Vulvar Adenocarcinoma after Neoadjuvant Chemotherapy: A Case Report and a Literature Review

Table 1

The literature reported vulvar intestinal adenocarcinoma cases.

Author, year	PTS age	Surgical treatment	Adjuvant treatment	Immunohistochemical pattern	PFS (months)
Tiltman and Knutzen, 1978 [5]	50	Modified RV + GD	NR	Not performed	12
Kennedy and Majmudar, 1993 [3]	Case  1: 54 years; Case  2: 63 years	RV + bilateral GD; Wide LE	NR; NR	CK+; CEA−	120; 48
Willen et al., 1999 [6]	57	Wide LE	NR	CK17+; Broad CK+; Polyclonal CEA+−; Chromogranin A+−	26
Nasir et al., 2001 [4]	43	EV + bilateral GD	NR	CEA+; p53+; Broad CK+; Ras10+−; ER−; PR−; Bcl2−; c-erB2−	18
Rodriguez et al., 2001 [7]	69	Wide LE	NR	CK7+; CK20+−; OC125 apical; CEA apical; OC19.9 apical	36
Liu et al., 2003 [9]	49	LE + bilateral GD	NR	Not performed	24
Dubè et al., 2004 [8]	58	Radical EV + ipsilateral GD	NR	CK20+−; CK7+; ER−; PR−	16
Ghamande et al., 1995 [2]	67	RV + bilateral GD	NR	CEA+	17
Cormio et al., 2012 [10]	Case  1: 58 years; Case  2: 42 years	EV + GD; RV + GD	Chemotherapy; NR	CK7+; CK 20+−	54; 39
Karkouche et al., 2012 [11]	31	LE	NR	CK 20+; CK 7−	15
Our case	57	NACT + LE + ipsilateral GR	—	CK 20+; CEA+; P16+; CDX2+ focal; Ca125+−; ER−; CK 7−; Vimentin−	17

LE: local excision, E: emivulvectomy, RV: radical vulvectomy, GD: groin dissection, NACT: neoadjuvant chemotherapy, NR: not reported.