Case Reports in Otolaryngology

Case Reports in Otolaryngology / 2020 / Article

Case Report | Open Access

Volume 2020 |Article ID 8435140 | https://doi.org/10.1155/2020/8435140

Allen Young, Lauran Evans, Matthew Ng, "Middle Ear Salivary Choristoma: A Rare Case Report and Update on Congenital Associations, Facial Nerve Involvement, and Treatment Strategies", Case Reports in Otolaryngology, vol. 2020, Article ID 8435140, 8 pages, 2020. https://doi.org/10.1155/2020/8435140

Middle Ear Salivary Choristoma: A Rare Case Report and Update on Congenital Associations, Facial Nerve Involvement, and Treatment Strategies

Academic Editor: Dinesh K. Chhetri
Received11 Aug 2019
Accepted04 Aug 2020
Published25 Aug 2020

Abstract

Salivary gland choristoma is an extremely rare middle ear mass and is hypothesized to be caused by second branchial arch developmental anomalies. We present a 14-year-old girl with Dandy–Walker syndrome and conductive hearing loss. Middle ear exploration revealed a large middle ear mass with absent incus and stapes and displaced facial nerve. The mass was completely excised with histological confirmation of salivary gland choristoma. Her hearing was improved with bone-anchored hearing aids (BAHA). As facial nerve involvement is common, physicians should consider partial excision to avoid facial nerve palsy. Hearing restoration can be achieved with OCR or BAHA.

1. Introduction

A choristoma is a congenital, benign overgrowth of mature tissue found in an abnormal location of the body. On extremely rare occasions, benign salivary gland tissue can be present in the middle ear cavity. Presenting symptoms include conductive hearing loss, ear fullness, tinnitus, otalgia, and otorrhea [1, 2]. These salivary gland choristomas are also associated with malformations of the ossicular chain, particularly the incus and stapes, along with dehiscence of the facial nerve from the fallopian canal [2, 3]. Their rare presentation and proximity to vital structures of the middle ear make diagnosis and treatment a challenge. We present a case report detailing this rare presentation along with an extensive review of previous cases with associated congenital findings, facial nerve involvement and its impact on surgery, and hearing augmentation outcomes.

2. Methods

We present a unique clinical case from our institution that is in line with the Surgical Case Report (SCARE) criteria along with a thorough literature review of all salivary gland choristomas, focusing on congenital and middle ear malformations, facial nerve involvement, treatments, and outcomes [4]. Statistical analysis was performed with Fisher’s exact test using Statistical Analysis Software (SAS) version 9.4.

3. Case Report

A 14-year-old female with a history of Dandy–Walker syndrome, hydrocephalus with ventriculoperitoneal shunt placement, and recurrent otitis media presented to our academic center with left hearing loss and aural fullness. Tympanostomy tubes were placed in each ear 5 years prior. Her mother states the hearing loss was present since birth and denies any otorrhea, otalgia, aural bleeding, dizziness, vertigo, or familial hearing loss. Audiogram showed normal hearing on the right and a moderate-severe rising to moderate mixed hearing loss with 25–50 dB air-bone gap on the left. Word recognition scores were excellent bilaterally (Figure 1). Tympanogram was type A for the right and type B for the left (Figure 2). CT temporal bone showed a left mesotympanic and hypotympanic mass extending into the infracochlear space. The scutum was sharp. There was no visible stapes. There was no direct continuity between the mass and the carotid or jugular bulb (Figures 3 and 4).

On examination, the left tympanic membrane had a shallow retraction pocket in the pars flaccida and a white retrotympanic mass suspicious for a possible secondary-acquired cholesteatoma. The decision was made to perform an exploratory tympanotomy and removal of the mass.

Under continuous facial nerve monitoring, tympanomeatal flap was elevated by a senior otology surgeon who uncovered a white, smooth, and mildly pulsatile mass. Compression of the external jugular veins and increased vagal pressure did not expand the mass. Mild compression of the mass did not cause blanching. Electrical stimulation of the mass at the inferior pole of the tumor and marching superiorly showed no electromyography (EMG) response. Bone removal from the canal floor was required to gain better access to the tumor. The tumor was first mobilized from its infracochlear position followed by the superior pole using curved dissectors. Total tumor removal was possible without any facial nerve stimulation.

After complete tumor removal, middle ear inspection revealed malformed long process of the incus without a stapes superstructure or oval window niche for reconstruction. An inferiorly displaced tympanic segment of the facial nerve was identified and was able to be electrically stimulated.

Pathology showed a 1 cm polypoid mass of respiratory sinus mucosa lined with pseudostratified columnar ciliated epithelium and scattered goblet cells, consistent with a salivary gland choristoma of the middle ear. There was no dysplasia or malignancy identified. On 2-week postoperative visit, she had no facial nerve weakness, and her aural fullness had improved, much to her satisfaction. Although ossicular chain reconstruction was not possible intraoperatively due to nonvisualized oval niche, the patient showed promising hearing response to a bone-anchored hearing aid (BAHA).

4. Discussion

Salivary gland choristoma in the middle ear cavity is an extremely rare condition with fewer than 50 cases ever reported [1, 2]. There appears to be a left-sided and female predominance, with age ranging from 9 months to 52 years old [5].

Salivary gland choristoma of the middle ear is hypothesized to form from malformation of the second branchial arch prior to the fourth month of gestation [4, 6]. Salivary tissue becomes trapped in the middle ear during the fusion of the tympanic ring with the temporal bone [7]. Abnormal second branchial arch development may also underpin the frequent findings of malformed incus, stapes, and facial nerve canal [7].

Although the abnormal deposition of tissue is often isolated to the middle ear, a unique developmental syndrome may be present [5, 6]. Several ipsilateral auricle and facial abnormalities have been associated with salivary choristomas, including alopecia [4, 8], auricle deformities and swelling [9], preauricular fistulas [10], and facial asymmetry [6]. Dandy–Walker syndrome is a congenital hypoplasia of the cerebellar vermis, dilation of the fourth ventricle, and enlarged posterior fossa. To date, this syndrome has not been known to be related to any choristomas. However, Buckmiller et al. described a case of an encephalocele in a child with a contralateral middle ear salivary choristoma [5] (Table 1).


AuthorsYearAgeSexLateralityCongenital defectsMiddle ear malformationsFacial nerveSurgical excision vs. biopsyHearing augmentation repairPostoperative findings

Taylor et al. [11]196131FLNoneIncus, stapesYBiopsyNoHearing unchanged
Steffen et al. [12]196252FRNoneIncus, stapesBiopsyNoHearing unchanged
Noguera et al. [13]196419MLNoneIncus, stapesBiopsyOCRHearing unchanged
Caplinger et al. [14]196734FLAuricle swellingMalleus, incusExcisionNoHearing unchanged
Bruner et al. [15]19706FRNoneStapesYExcisionOCRHearing improved, transient facial palsy
Hociota et al.197550MLNoneStapesYExcisionNoFacial paralysis
Peron et al. [16]197520MBilateralDevelopmental delay, bilateral cholesteatomasMalleus, incus, stapesAutopsyNo
Mischke et al. [17]19779FLPostauricular cystic massMalleus, incusYBiopsyNo.
Wine et al. [18]197720MLNoneYBiopsyNoHearing improved
Abadir et al. [7]197821FLMicrotiaIncus, stapesYExcisionOCRHearing unchanged
Kley et al. [19]197946FRNoneYExcisionYesHearing improved
Cannon et al. [10]198024FRAuricle swellingIncus, stapesNExcisionNo
Quaranta et al. [9]198123MLAlopeciaIncusExcisionNo.
Saeger et al. [20]198217MLNoneIncusYBiopsyNo.
Saeger et al. [20]198210FLNoneMalleus, incusNExcisionYes.
Moore et al. [21]19845FLNoneIncus, stapesExcisionNo
Kartush et al. [22]198419FRAuricle swellingIncusBiopsyNoHearing unchanged
Bottrill et al. [23]199210MRNoneIncus, stapes.NExcisionNoHearing improved
Cejas-Mendez et al. [24]19923FLEAC malformation.NExcisionNoHearing unchanged
Munster et al. [25]199416MRNoneIncus, stapesNBiopsyNo.
Namdar et al. [5]19956FLEAC malformationIncus, stapesYBiopsyNoHearing unchanged
Hinni et al. [26]19969MLNoneMalleus, incus, stapesNExcisionNo.
Anderhuber et al. [27]19964MLNoneIncus, stapesNExcisionNoHearing unchanged
Perry et al. [28]19985MLBranchial cleft cystIncusYBiopsyNo
Morimoto et al. [3]199913MLAlopeciaIncus, stapesYExcisionNo
Supiyaphun et al. [29]200010FLEAC malformationMalleus, incus, stapesYExcisionNoHearing unchanged
Ha et al. [30]20003FRNoneNoneNExcisionNoHearing unchanged
Vasama et al. [8]2001..R.IncusY...
Buckmiller et al. [6]20010.75MRFacial asymmetry, bilateral preauricular pits, encephalocele, Mondini-type deformitiesIncus, stapesExcisionNo.
Ookuchi et al.20031FRNoneIncus, stapesYBiopsyNo
Simoni et al. [31]20030.83FLTonsillar teratoid polypNoneNExcisionNoHearing unchanged
Enoz et al. [32]200614FLNoneStapesYBiopsyNo
Yazici et al.200632FLNoneStapesNExcisionNoHearing unchanged
Lee et al. [33]20060.9166FRNoneIncus, stapesNExcisionOCRHearing improved
Boleas-Aguirre et al. [34]200612ML.Incus, stapesN...
Nassar et al. [35]200732MRNoneIncus, stapesYExcisionOCRHearing improvement, transient facial nerve palsy
Toros et al. [36]20107FRSitus inversusIncusNExcisionOCRHearing improved
Gomez et al.201332FLNoneNormalBiopsyNoFacial nerve palsy
Amrhein et al. [37]20140.83FRBranchio-oto-renal syndrome. Developmental delay, bilateral preauricular pits, ear tag, dysplastic auricleMalleus, incus, stapesExcisionOCR, BAHAHearing unchanged
Fois et al. [38]201422FLNoneIncus, stapesNExcisionOCRHearing improved
Chen et al. [39]20156FLPreauricular pitYBiopsyNoHearing unchanged
Noda et al. [40]201610FLAlopeciaStapesYBiopsyOCRHearing improved
Aghazadeh et al. [1]201641MRNoneStapesNExcisionNoHearing improved
Ziari et al. [41]201639MLNoneStapesNExcisionNoHearing improved
Su et al. [42]20198FLPharyngeal hamartomaMalleus, incusNExcisionYesHearing unchanged
Purnell et al. [43]20196MLEar tagIncusNExcisionOCR
Current case201914FLDandy–WalkerIncus, stapesNExcisionBAHAHearing improved

F: female, M: male, R: right, L: left, Y: yes, and N: no. All unfilled boxes indicate information that was unspecified in the case reports.

CT imaging and otomicroscopic appearance are usually sufficient to presumptively diagnose middle ear pathology before making the first incision. However, due to the rarity of middle ear salivary choristoma, it is often misdiagnosed as cholesteatoma given its white, retrotympanic appearance [37] or otosclerosis due to the unilateral conductive hearing loss [8, 38]. Only one case had concurrent cholesteatomas with a middle ear salivary choristoma [35]. Regardless of initial diagnosis, exploratory tympanotomy is warranted in all cases. Intracranial and vascular tumors can be ruled out through a preoperative CT scan, enlarging mass during increased intracranial pressure through Valsalva or occlusion of internal jugular veins (Queckenstedt maneuver), and blanching of mass during manipulation. Histopathology of the middle ear mass is required for diagnosis confirmation.

Malignant transformation of salivary choristoma is rare [16], and many authors in the literature suggest that complete tumor excision is not necessary [10, 44]. However, others propose that the small chance of malignant transformation does warrant complete excision [45].

The major limiting factor for complete surgical excision is facial nerve involvement. Cases involving the facial nerve had a significantly lower complete excision rate than those in which the facial nerve was spared (44.4% vs. 84.2%, , Table 2). Permanent facial nerve palsy after removal of a middle ear salivary choristoma has occurred in two reported cases [36, 46], with two additional cases of transient facial nerve palsy that later recovered [38, 47]. To mitigate this risk of facial nerve palsy in all cases, use of a facial nerve monitor during surgery is strongly recommended [4, 44]. The abnormal and dehiscent course of the facial nerve makes it vulnerable to injury during middle ear dissection. Facial nerve electrical stimulation should be applied to the mass at areas prior to surgical manipulation to ensure the facial nerve is not in close proximity, and electrocautery of the mass should be avoided. Partial excision of mass can be considered to avoid facial nerve palsy.


Facial nerveTotalComplete excisionBiopsy/partial excision value

Involved188 (44.4%)10 (55.6%)0.0027
Not involved1916 (84.2%)1 (5.2%)

Complete excision vs. biopsy/partial excision has different risks to the facial nerve. Two cases that had no facial nerve involvement and did not specify the exact procedure may underestimate the risk of facial nerve involvement during complete excision.

Ossicular chain reconstruction has been attempted both during initial removal [45] and staged months after removal [37] for restoration of hearing, with promising results (Table 3). Hearing was significantly improved in patients who underwent OCR than those without repair (58.3% vs. 12.9%, ). In our present case, OCR was not attempted due to inaccessibility of the oval window niche. However, bone-anchored hearing aids (BAHA) can provide a viable alternative to hearing enhancement as our patient showed encouraging response on BAHA demo.


Hearing repairTotalHearing improvementNo improvement or no follow-up recorded value

Ossicular chain reconstruction (OCR)127 (58.3%)5 (41.7%)0.0047
No repair314 (12.9%)27 (87.1%)

5. Conclusion

Salivary gland choristoma is an extremely rare diagnosis of a middle ear mass. Radiographic imaging and careful middle ear exploration are needed to rule out vascular and intracranial tumors. As facial nerve involvement is common, physicians may consider partial excision to avoid facial nerve palsy. Hearing restoration can be achieved with ossicular chain reconstruction or BAHA.

Written telephone informed consent was obtained from the parental guardians of the patient for publication of this case report and accompanying images.

Conflicts of Interest

The authors report no conflicts of interest.

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