Late-Onset Neutropenia in Long-Term Clozapine Use and Its Management Utilizing Prophylactic G-CSF

Figure 3

Administration of filgrastim resulting in increases in neutrophil levels. Figure 3 demonstrates the administration of filgrastim 30 MU, given as needed in response to neutropenia occurring from March 2019, in keeping with the patient specific protocol supported by hematology. The axis shows the timeline of the filgrastim administration, and the axis displays the absolute neutrophil count ×10⁹/L. The blue columns represent the ANC prior to giving filgrastim, and the orange columns represent ANCs one day postfilgrastim administration. Green light results indicating safe ANCs are seen from July 2019 utilizing prophylactic filgrastim up to three times weekly.