Single-Stage Craniectomy and Cranioplasty for Multilobular Osteochondrosarcoma Managed with a Custom Additive Manufactured Titanium Plate in a Dog

Figure 10

(a) Inflamed granulation tissue immediately under the titanium plate. Note the moderate, predominantly neutrophilic inflammation (bar = 300 µm; H&E stain). (b) Tapering of the inflammation towards the porcine SIS with lymphoplasmacytic predominance and abundant small caliber blood vessels supporting neovascularization (bar = 300 µm; H&E stain). (c) Porcine SIS with appropriate vascularization and no evidence of inflammation immediately covering the brain (bar = 300 µm; H&E stain). (d) Photomicrograph of sinus epithelium revealing a mild to moderate neutrophilic and lymphoplasmacytic sinusitis (bar = 250 µm; H&E stain). (e) Photomicrograph of the multilobular osteochondrosarcoma at the time of surgical excision, revealing lobules of thick tendrils of spindle cells that are enclosing plump polygonal cells admixed with abundant extracellular eosinophilic matrix, interpreted as osteoid, findings typical of this neoplasm (bar = 250 µm; H&E stain). (f) Photomicrograph of the multilobular osteochondrosarcoma regrowth revealing similar organization as previously noted (Figure 10(e)) with slightly less cellular atypia and more organized lobules (bar = 250 µm; H&E stain).

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