MicroRNA-101-3p Suppresses mTOR and Causes Mitochondrial Fragmentation and Cell Degeneration in COPD

Figure 7

The additive effect of miR-101-3p and TNF-α on ASMC deterioration. (a) Western blots of disease-specific 24 hours effect for miR-101-3p mimics and inhibitors on the baseline expression of fibronectin and α-SMA expression in AMSC of healthy nonsmokers (n = 3) and COPD (n = 3). (b) Image analysis of fibronectin Western blots in ASMC of healthy nonsmokers and COPD, as shown in Figure 7(a). (c) Image analysis of α-SMA Western blots in ASMC of healthy nonsmokers and COPD, as shown in Figure 7(a). Bars represent mean ± S.E.M. “” =  and “” =  are compared to untreated ASMC.

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