Cardiology Research and Practice / 2012 / Article / Tab 2

Review Article

The Diabetic Heart: Too Sweet for Its Own Good?

Table 2

Studies indicating the diabetic heart is less sensitive to ischemic injury compared to normoglycaemic controls.

StudyModelIschemic ProtocolDuration/onset of diabetesSubstratesModel of diabetesEnd points

Hadour et al. (1998) [48]Rabbit, alloxan (100 mg/kg)In vivo nonrecovery, 30 min regional ischemia/3 hr reperfusion2 monthsIn vivo substratesType I diabetesInfarction

Schaffer et al. (2000) [49]Rat, neonatal cardiomyocytes10 mM deoxyglucose and and 3 mM amobarbital medium for 1 hr, OR hypoxic chamber: 2.3% O2–5% CO2-balance N2 for 1 hr3-day incubation with 25 mM glucose in mediumType I diabetesInfarction

Oliveria et al. (2001) [50]Goto Kakizaki Rat, male, isolated cardiomyocyte mitochondriaIn-bred strainType II diabetesCell death and mPTP

Nawata et al. (2002) [51]Rat, STZ (65 mg/kg)Langendorff isolated heart, 30 min low flow global ischemia/30 min reperfusion4 weeks11 mmol/L glucoseType I diabetesMyocardial function

Ooie et al. (2003) [52]Rat, STZ (65 mg/kg)Langendorff isolated heart: Low-flow global ischemia for 5 min, followed by no-flow ischemia for 25 min. 30 min reperfusion12 weeks11 mmol/L glucoseType I diabetesMyocardial function, creatine kinase release

Ravingerová et al. (2003) [53]Rat, STZ (45 mg/kg)In vivo non recovery, 30 min regional ischemia/4 hr reperfusion1 weekIn vivo substratesType I diabetesInfarction

Kristiansen et al. (2004) [54]Goto Kakizaki Rat, maleLangendorff isolated heart, 50 min regional ischemia/2 hr reperfusionIn-bred strain11 mmol/L glucoseType II diabetesInfarction

Kristiansen et al. (2004) [54]Obese Zucker Diabetic Fatty Rat, maleLangendorff isolated heart, 50 min regional ischemia/2 hr reperfusionIn-bred strain11 mmol/L glucoseType II diabetesInfarction

Tsang et al. (2005) [55]Goto Kakizaki Rat, maleLangendorff isolated heart, 30 min regional ischemia/2 hr reperfusionIn-bred strain11 mmol/L glucoseType II diabetesInfarction, kinase expression

Ma et al. (2006) [56]Rat, STZ (50 mg/kg)In vivo non recovery, 30 min regional ischemia/2 hr reperfusion2 weeksIn vivo substratesType I diabetesInfarction

Chu et al. (2010) [57]Yucatan pigs, alloxan (200 mg/kg)In vivo non recovery, 1 hr regional ischemia/2 hr reperfusion5 weeksIn vivo substratesType I diabetesInfarction and protein expression

Shi-Ting et al. (2010) [58]Rat, STZ (60 mg/kg)Langendorff isolated heart, 30 min regional ischemia/40 min reperfusion4 weeks11 mmol/L glucoseType I diabetesInfarction and creatine kinase release